Reactome: A Curated Pathway Database

DHF is reduced to tetrahydrofolate (THF)

Stable Identifier
R-HSA-197972
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic dihydrofolate reductase catalyzes the reaction of dihydrofolate, NADPH, and H+ to form tetrahydrofolate (THF) and NADP+ (Chen et al. 1984; Davies et al. 1990).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
folate reductase activity of DHFR [cytosol] DHFR [cytosol] folate reductase activity (0033560)
Orthologous Events
Cross References
Rhea