Reactome | NOTCH1 binds DLL1

NOTCH1 binds DLL1

Stable Identifier

R-HSA-1980039

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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The NOTCH1 receptor is activated by binding Delta-like 1 ligand (DLL1), presented on the plasma membrane of a neighboring cell (Jarriault et al. 1998). EGF repeat 12 (EGF12) in the extracellular domain of NOTCH1 appears to be particularly important for interaction of NOTCH1 with DLL1 (Cordle et al. 2008). The affinity of NOTCH1 for DLL1 is increased when NOTCH1 is glycosylated by fringe enzymes (Yang et al 2005).

Literature References

PubMed ID	Title	Journal	Year
18296446	Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity van der Merwe, PA, Stacey, M, Willis, AC, Redfield, C, Champion, BR, Cordle, J, Handford, PA, Hambleton, S	J Biol Chem	2008
15574878	Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1 Manilay, JO, Nichols, JT, Yang, LT, Robey, EA, Weinmaster, G, Yao, C	Mol Biol Cell	2005
9819428	Delta-1 activation of notch-1 signaling results in HES-1 transactivation Logeat, F, Seidah, NG, Hirsinger, E, Jarriault, S, Strong, CF, Pourquie, O, Isra, l A, Le, Bail O, Brou, C	Mol Cell Biol	1998