NOTCH1 binds DLL1

Stable Identifier
R-HSA-1980039
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The NOTCH1 receptor is activated by binding Delta-like 1 ligand (DLL1), presented on the plasma membrane of a neighboring cell (Jarriault et al. 1998). EGF repeat 12 (EGF12) in the extracellular domain of NOTCH1 appears to be particularly important for interaction of NOTCH1 with DLL1 (Cordle et al. 2008). The affinity of NOTCH1 for DLL1 is increased when NOTCH1 is glycosylated by fringe enzymes (Yang et al 2005).

Literature References
PubMed ID Title Journal Year
15574878 Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1

Yang, LT, Nichols, JT, Yao, C, Manilay, JO, Robey, EA, Weinmaster, G

Mol Biol Cell 2005
18296446 Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity

Cordle, J, Redfield, C, Stacey, M, van der Merwe, PA, Willis, AC, Champion, BR, Hambleton, S, Handford, PA

J Biol Chem 2008
9819428 Delta-1 activation of notch-1 signaling results in HES-1 transactivation

Jarriault, S, Le, Bail O, Hirsinger, E, Pourquie, O, Logeat, F, Strong, CF, Brou, C, Seidah, NG, Isra, l A

Mol Cell Biol 1998
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