The NOTCH1 receptor is activated by binding Delta-like 1 ligand (DLL1), presented on the plasma membrane of a neighboring cell (Jarriault et al. 1998). EGF repeat 12 (EGF12) in the extracellular domain of NOTCH1 appears to be particularly important for interaction of NOTCH1 with DLL1 (Cordle et al. 2008). The affinity of NOTCH1 for DLL1 is increased when NOTCH1 is glycosylated by fringe enzymes (Yang et al 2005).
van der Merwe, PA, Stacey, M, Willis, AC, Redfield, C, Champion, BR, Cordle, J, Handford, PA, Hambleton, S
Manilay, JO, Nichols, JT, Yang, LT, Robey, EA, Weinmaster, G, Yao, C
Logeat, F, Seidah, NG, Hirsinger, E, Jarriault, S, Strong, CF, Pourquie, O, Isra, l A, Le, Bail O, Brou, C
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