Cleavage of DNER:NOTCH1 complex releases NICD1

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R-HSA-1980112
Type
Reaction [omitted]
Species
Homo sapiens
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Binding of DNER to NOTCH1 induces gamma-secretase dependent cleavage of NOTCH1 at the S3 cleavage site and releases NOTCH1 intracellular domain into the cytosol. Cleavage of NOTCH1 at the S2 cleavage site by ADAM10/17, which should precede cleavage at the S3 site, has not been studied in the context of DNER-mediated NOTCH1 activation.

Literature References
PubMed ID Title Journal Year
15965470 DNER acts as a neuron-specific Notch ligand during Bergmann glial development

Eiraku, M, Tohgo, A, Ono, K, Kaneko, M, Fujishima, K, Hirano, T, Kengaku, M

Nat Neurosci 2005
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