ARRB mediates NOTCH1 ubiquitination

Stable Identifier
R-HSA-1980118
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Ubiquitination of NOTCH1 mediated by DTX-recruited beta-arrestins (ARRB) has not been directly studied in mammals. Non-visual beta arrestins ARRB1 and ARRB2 are known to facilitate ubiquitination and downregulation of GPCRs and IGF1R.

Literature References
PubMed ID Title Journal Year
16284625 Regulation of Notch signalling by non-visual beta-arrestin

Mukherjee, A, Veraksa, A, Bauer, A, Rosse, C, Camonis, J, Artavanis-Tsakonas, S

Nat Cell Biol 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of Ubiquitin ligase [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created