DTX recruits beta-arrestin (ARRB) to NOTCH

Stable Identifier
R-HSA-1980123
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Formation of a complex involving NOTCH, Deltex (DTX) and non-visual beta-arrestin (ARRB) has not been directly studied in mammalian cells. The mammalian non-visual beta-arrestins ARRB1 and ARRB2 play a major role in desensitization and endocytosis of G-protein-coupled receptors (GPCRs), and their interaction with GPCRs involves N-terminal beta-arrestin sequences that are homologous to the Deltex-binding N-terminus of Drosophila Kurtz (Mukherjee et al. 2005). Shrub, a core component of the ESCRT-III complex, was recently identified as an important modulator of non-visual beta-arrestin-mediated downregulation of Notch in Drosophila (Hori et al. 2011).

Literature References
PubMed ID Title Journal Year
22162134 Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal

Hori, K, Sen, A, Kirchhausen, T, Artavanis-Tsakonas, S

J Cell Biol 2011
16284625 Regulation of Notch signalling by non-visual beta-arrestin

Mukherjee, A, Veraksa, A, Bauer, A, Rosse, C, Camonis, J, Artavanis-Tsakonas, S

Nat Cell Biol 2005
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