NOTCH1 binds DLL/JAG ligand in cis

Stable Identifier
R-HSA-1980138
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Binding of NOTCH1 to DLL/JAG ligands expressed in the same cells (in cis) blocks NOTCH1 activation by DLL/JAG ligands expressed on neighboring cells (in trans). Cis-inhibiton of NOTCH signaling can amplify small differences in NOTCH and DLL/JAG levels between neighboring cells.

Literature References
PubMed ID Title Journal Year
20418862 Cis-interactions between Notch and Delta generate mutually exclusive signalling states

Sprinzak, D, Lakhanpal, A, LeBon, L, Santat, LA, Fontes, ME, Anderson, GA, Garcia-Ojalvo, J, Elowitz, MB

Nature 2010
18660822 A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

Cordle, J, Johnson, S, Tay, JZ, Roversi, P, Wilkin, MB, Hernandez de Madrid Diaz, B, Shimizu, H, Jensen, S, Whiteman, P, Jin, B, Redfield, C, Baron, M, Lea, SM, Handford, PA

Nat Struct Mol Biol 2008
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