Reactome | TNFRSF14 [plasma membrane]

TNFRSF14 [plasma membrane]

Stable Identifier

R-HSA-198101

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

HVEM, Tumor necrosis factor receptor superfamily member 14 precursor, TR14_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q3SYB3 FX4L6

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External Reference Information

External Reference

UniProt:Q92956 TNFRSF14

Gene Names

TNFRSF14, HVEA, HVEM, UNQ329/PRO509

Chain

signal peptide:1-38, chain:39-283

Reference Genes

BioGPS Gene:8764 TNFRSF14

COSMIC (genes):TNFRSF14 TNFRSF14

CTD Gene:8764 TNFRSF14

dbSNP Gene:8764 TNFRSF14

ENSEMBL:ENSG00000157873 TNFRSF14

HGNC:11912 TNFRSF14

KEGG:hsa:8764 TNFRSF14

Monarch:8764 TNFRSF14

NCBI Gene:8764 TNFRSF14

OMIM:602746 TNFRSF14

UCSC:Q92956 TNFRSF14

Reference Transcript

Other Identifiers

11743194_x_at

11745772_x_at

11745773_a_at

11745894_x_at

11746529_x_at

11760116_x_at

11762908_x_at

16658064

17119878

209354_PM_at

209354_at

2392610

2392611

2392612

2392613

2392614

2392615

2392616

2392617

2392618

2392619

2392620

2392621

2392622

2392623

2392624

2392625

2392626

2392627

2392628

2392629

2392630

2392631

2392632

2392633

2392634

2392635

2392636

2392637

2392641

2392642

2392643

2392644

2392645

2392646

2392647

2392648

39424_at

7911754

8764

A_23_P126908

A_33_P3248962

A_33_P3286302

GE81324

GO:0001618

GO:0002250

GO:0002376

GO:0002720

GO:0005031

GO:0005515

GO:0005886

GO:0006955

GO:0007166

GO:0009897

GO:0016020

GO:0019955

GO:0031295

GO:0031625

GO:0033209

GO:0045087

GO:0046642

GO:0046718

GO:0050731

GO:0050829

GO:0050830

GO:0060089

GO:0098542

GO:1905675

GO:2000406

HMNXSV003031545

HMNXSV003037999

ILMN_1697409

PH_hs_0014422

TC01000061.hg

U70321_at

g12803894_3p_at

Participates

as a member of

TNFRSF1A,1B,14 [plasma membrane] (Homo sapiens)

as an input of

BTLA interacts with HVEM (Homo sapiens)

as a component of

Inferred To

fc41c11 [plasma membrane] (Danio rerio)

si:dkey-23c22.6 [plasma membrane] (Danio rerio)

TNFRSF14 [plasma membrane] (Canis familiaris)

Tnfrsf14 [plasma membrane] (Mus musculus)

Tnfrsf14 [plasma membrane] (Rattus norvegicus)

Homologues of TNFRSF14 [plasma membrane] (Danio rerio)

Cross References

Guide to Pharmacology - Targets

1887

ENSEMBL

ENST00000621877, ENSP00000347948, ENSP00000478308, ENST00000355716

OpenTargets

ENSG00000157873

HPA

ENSG00000157873-TNFRSF14

PRO

Q92956

Pharos - Targets

Q92956

GlyGen

Q92956

PDB

4RSU, 7MSG, 4FHQ, 6NG3, 2AW2, 5T2Q, 5T2R, 1JMA

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43557 TNFSF14	1	TNFSF14 [plasma membrane] (R-HSA-5667149)	0.743	5
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.692	3
UniProt:O00463 TRAF5			0.646	5
UniProt:Q12933-2 TRAF2			0.646	4
UniProt:Q3SYB3 FX4L6			0.556	3