Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-T566,T710,S729-PRKCE [plasma membrane]
Stable Identifier
R-HSA-198260
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Phospho-Protein kinase C-epsilon, nPKC-epsilon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Role of phospholipids in phagocytosis (Homo sapiens)
DAG stimulates protein kinase C-delta (Homo sapiens)
Phospho-PKC-delta/epsilon [plasma membrane] (Homo sapiens)
p-T566,T710,S729-PRKCE [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
DAG stimulates protein kinase C-delta (Homo sapiens)
Phospho-PKC-delta/epsilon [plasma membrane] (Homo sapiens)
p-T566,T710,S729-PRKCE [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
SHC1 events in ERBB2 signaling (Homo sapiens)
Activated PKC phosphorylates SHC1 (Homo sapiens)
Activated PRKCA,(PRKCD,PRKCE) [plasma membrane] (Homo sapiens)
DAGs:active p-T566,T710,S729-PRKCE [plasma membrane] (Homo sapiens)
p-T566,T710,S729-PRKCE [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02156 PRKCE
Gene Names
PRKCE, PKCE
Chain
chain:1-737
Reference Genes
BioGPS Gene:5581 PRKCE
COSMIC (genes):PRKCE PRKCE
CTD Gene:5581 PRKCE
dbSNP Gene:5581 PRKCE
ENSEMBL:ENSG00000171132 PRKCE
HGNC:9401 PRKCE
KEGG:hsa:5581 PRKCE
Monarch:5581 PRKCE
NCBI Gene:5581 PRKCE
OMIM:176975 PRKCE
UCSC:Q02156 PRKCE
Reference Transcript
RefSeq:NM_005400.2 PRKCE
RefSeq:XM_005264428.1 PRKCE
Other Identifiers
11736257_at
11736258_a_at
206248_PM_at
206248_at
226101_PM_at
226101_at
236459_PM_at
236459_at
2480169
2480170
2480171
2480172
2480184
2480185
2480186
2480192
2480193
2480199
2480200
2480201
2480202
2480203
2480219
2480223
2480224
2480225
2480228
2480231
2480253
2480254
2480255
2480256
2480257
2480258
2480261
2480263
2480264
2480265
2480269
2480270
2480295
2480300
2480316
2480319
2480320
2480321
2480322
2480323
2480332
2480333
2480334
2480335
2480336
2480337
2480338
2480339
32891_at
417_at
49044_at
5581
59772_at
8041763
A_14_P202202
A_23_P250564
A_23_P348194
A_33_P3252191
GO:0000165
GO:0002281
GO:0002376
GO:0003785
GO:0003824
GO:0004672
GO:0004674
GO:0004697
GO:0004699
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005783
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0006468
GO:0006915
GO:0007155
GO:0007165
GO:0008047
GO:0008092
GO:0009407
GO:0010634
GO:0010763
GO:0010811
GO:0012501
GO:0016020
GO:0016740
GO:0018105
GO:0019216
GO:0019899
GO:0023052
GO:0030073
GO:0030546
GO:0030838
GO:0031397
GO:0031589
GO:0031663
GO:0032024
GO:0032230
GO:0032467
GO:0032930
GO:0035276
GO:0035556
GO:0035641
GO:0035669
GO:0038096
GO:0043123
GO:0043226
GO:0043231
GO:0043278
GO:0043410
GO:0045111
GO:0045202
GO:0046872
GO:0048471
GO:0050730
GO:0050996
GO:0051279
GO:0051301
GO:0051649
GO:0051932
GO:0061178
GO:0070254
GO:0070257
GO:0071361
GO:0071380
GO:0071456
GO:0071889
GO:0071944
GO:0080090
GO:0090303
GO:0098754
GO:0098772
GO:0106310
GO:0140096
GO:1902306
GO:1903078
GO:2001031
HMNXSV003011483
HMNXSV003016379
Hs.179991.0.A1_3p_at
Hs.179991.0.A1_3p_x_at
Hs.24379.0.A1_3p_at
ILMN_1717799
PH_hs_0022703
X65293_at
g4885562_3p_at
Participates
as a member of
Phospho-PKC-delta/epsilon [plasma membrane] (Homo sapiens)
as a component of
DAGs:active p-T566,T710,S729-PRKCE [plasma membrane] (Homo sapiens)
Other forms of this molecule
PRKCE [cytosol]
Inferred To
phospho-p-T566,T710,S729-PRKCE [plasma membrane]
(Caenorhabditis elegans)
phospho-p-T566,T710,S729-PRKCE [plasma membrane]
(Danio rerio)
phospho-p-T566,T710,S729-PRKCE [plasma membrane]
(Dictyostelium discoideum)
phospho-p-T566,T710,S729-PRKCE [plasma membrane]
(Drosophila melanogaster)
phospho-p-T566,T710,S729-PRKCE [plasma membrane]
(Gallus gallus)
phospho-p-T566,T710,S729-PRKCE [plasma membrane]
(Mus musculus)
phospho-p-T566,T710,S729-PRKCE [plasma membrane]
(Rattus norvegicus)
phospho-p-T566,T710,S729-PRKCE [plasma membrane]
(Saccharomyces cerevisiae)
phospho-p-T566,T710,S729-PRKCE [plasma membrane]
(Schizosaccharomyces pombe)
phospho-p-T566,T710,S729-PRKCE [plasma membrane]
(Sus scrofa)
Homologues of p-T566,T710,S729-PRKCE [plasma membrane]
(Dictyostelium discoideum)
Homologues of p-T566,T710,S729-PRKCE [plasma membrane]
(Schizosaccharomyces pombe)
phospho-PRKCE [plasma membrane]
(Canis familiaris)
Modified Residues
Name
O-phospho-L-threonine at 566
Coordinate
566
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 710
Coordinate
710
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
Guide to Pharmacology - Targets
1486
ENSEMBL
ENSG00000171132
,
ENSP00000306124
,
ENST00000306156
OpenTargets
ENSG00000171132
ZINC - FDA approved
KPCE_HUMAN
ZINC - Substances
KPCE_HUMAN
ZINC - Biogenic
KPCE_HUMAN
ZINC target
Q02156
PRO
Q02156
PDB
2WH0
,
5LIH
ZINC - Investigational
KPCE_HUMAN
IntEnz
2.7.11.13
GeneCards
PRKCE
HPA
ENSG00000171132-PRKCE
Pharos - Targets
Q02156
ZINC - Predictions - Purchasable
KPCE_HUMAN
HMDB Protein
HMDBP01852
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.729
7
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
0.641
4
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.589
3
UniProt:P17252 PRKCA
8
PRKCA [cytosol]
(R-HSA-58196)
pT497,T638,S657-PRKCA [plasma membrane]
(R-HSA-4332340)
p-T497,T638,S657-PRKCA [cytosol]
(R-HSA-4332337)
PRKCA [plasma membrane]
(R-HSA-156469)
p-T497,T638,S657-PRKCA [nucleoplasm]
(R-HSA-5223292)
p-T497-PRKCA [cytosol]
(R-HSA-5218731)
PRKCA [photoreceptor disc membrane]
(R-HSA-2648987)
PRKCA [nucleoplasm]
(R-HSA-450530)
0.564
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.564
4
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.564
2
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
