DAG stimulates protein kinase C-delta

Stable Identifier
R-HSA-198314
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Diacylglycerol (DAG) positively regulates the autophosphorylation of protein kinase C-delta (PKC-delta), which stimulates ERK1/2 and triggers neurite outgrowth. DAG also stimulates the translocation of PKC from the cytosol to the plasma membrane. PKC-delta contributes to growth factor specificity and response to neuronal cells by promoting cell-type-specific differences in growth factor signalling. DAG can also activate PKC-epsilon in the same manner (Newton 2001).

Literature References
PubMed ID Title Journal Year
11749377 Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

Newton, AC

Chem. Rev. 2001
16678913 PKD at the crossroads of DAG and PKC signaling

Wang, QJ

Trends Pharmacol. Sci. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein kinase C activity of PKC-delta/epsilon [cytosol]
Physical Entity
Activity
This event is regulated
Positively by
Orthologous Events
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