Active IRS recruits PI3K to the plasma membrane and activates it

Stable Identifier
R-HSA-198315
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
ReviewStatus
5/5
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Active IRS recruits PI3K to the plasma membrane and activates it
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The PI3K regulatory subunit p85 binds to IRS1 or IRS2, tyrosine-phosphorylated at YXXM motifs, through its SH2 domain.
As the p85 subunt is constitutively associated with the p110 catalytic subunit, the outcome is that the whole PI3K complex is recruited to the membrane. The interaction at the plasma membrane of the p85 regulatory subunit with the p110 catalytic subunit of PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) causes a conformational change, resulting in activation of the catalytic subunit (Miranda et al. 2001).
Literature References
PubMed ID Title Journal Year
11147812 IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1

Van Obberghen, E, Miele, C, Miranda, C, Greco, A, Pierotti, MA

J Cell Physiol 2001
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Orthologous Events
Active IRS recruits PI3K to the plasma membrane and activates it (Bos taurus)
Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)
Active IRS recruits PI3K to the plasma membrane and activates it (Gallus gallus)
Active IRS recruits PI3K to the plasma membrane and activates it (Mus musculus)
Active IRS recruits PI3K to the plasma membrane and activates it (Rattus norvegicus)
Active IRS recruits PI3K to the plasma membrane and activates it (Sus scrofa)
Active IRS recruits PI3K to the plasma membrane and activates it (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
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