AKT phosphorylates BAD

Stable Identifier
R-HSA-198347
Type
Reaction [transition]
Species
Homo sapiens
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Activated AKT phosphorylates the BCL-2 family member BAD at serine 99 (corresponds to serine residue S136 of mouse Bad), blocking the BAD-induced cell death (Datta et al. 1997, del Peso et al. 1997, Khor et al. 2004).

Literature References
PubMed ID Title Journal Year
9346240 Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Datta, SR, Dudek, H, Tao, X, Masters, S, Fu, H, Gotoh, Y, Greenberg, ME

Cell 1997
15183529 Positive correlation between overexpression of phospho-BAD with phosphorylated Akt at serine 15183529

Khor, TO, Gul, YA, Ithnin, H, Seow, HF

Cancer Lett 2004
9381178 Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

del Peso, L, Gonzalez-Garcia, M, Page, CP, Herrera, R, Nunez, G

Science 1997
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Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
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