malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]

Stable Identifier
Reaction [transition]
Homo sapiens
Exchange of malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
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The SLC25A11 transport protein in the inner mitochondrial membrane mediates the reversible exchange of mitochondrial malate and cytosolic alpha-ketoglutarate (2-oxoglutarate). Qualitative evidence for this process comes from studies of the human protein (Kabe et al. 2006); kinetic details are inferred from stdies of rat mitochondria under conditions in which only the one transport protein appears to be active (Sluse et al. 1973). The dimeric state of the transport protein is inferred from studies of its bovine homologue (Bisaccia et al. 1996).

Literature References
PubMed ID Title Journal Year
8597574 The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier

Bisaccia, F, Zara, V, Capobianco, L, Iacobazzi, V, Mazzeo, M, Palmieri, F

Biochim Biophys Acta 1996
16920706 Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier

Kabe, Y, Ohmori, M, Sinouchi, K, Tsuboi, Y, Hirao, S, Azuma, M, Watanabe, H, Okura, I, Handa, H

J Biol Chem 2006
4687397 Mechanism of the exchanges catalysed by the oxoglutarate translocator of rat-heart mitochondria. Kinetics of the external-product inhibition

Sluse, FE, Goffart, G, LiƩbecq, C

Eur J Biochem 1973
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane]
Physical Entity
Orthologous Events