Reactome | SLC25A11 [mitochondrial inner membrane]

SLC25A11 [mitochondrial inner membrane]

Stable Identifier

R-HSA-198451

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Mitochondrial 2-oxoglutarate/malate carrier protein

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q02978 SLC25A11

Gene Names

SLC25A11, SLC20A4

Chain

initiator methionine:, chain:2-314

Reference Genes

BioGPS Gene:8402 SLC25A11

COSMIC (genes):SLC25A11 SLC25A11

CTD Gene:8402 SLC25A11

dbSNP Gene:8402 SLC25A11

ENSEMBL:ENSG00000108528 SLC25A11

HGNC:10981 SLC25A11

KEGG:hsa:8402 SLC25A11

Monarch:8402 SLC25A11

NCBI Gene:8402 SLC25A11

OMIM:604165 SLC25A11

UCSC:Q02978 SLC25A11

Reference Transcript

RefSeq:NM_003562.4 SLC25A11

Other Identifiers

11744261_a_at

11754024_a_at

11756183_x_at

16840145

207088_PM_s_at

207088_s_at

209003_PM_at

209003_at

32197_at

3742385

3742386

3742387

3742388

3742389

3742390

3742391

3742392

3742393

3742394

3742395

3742396

3742397

3742398

3742399

8011747

8402

A_23_P38497

GE61714

GO:0003723

GO:0005215

GO:0005515

GO:0005634

GO:0005739

GO:0005743

GO:0005886

GO:0005975

GO:0006094

GO:0006869

GO:0008272

GO:0015116

GO:0015117

GO:0015131

GO:0015140

GO:0015141

GO:0015297

GO:0015367

GO:0015709

GO:0015729

GO:0015742

GO:0016020

GO:0022857

GO:0035435

GO:0043226

GO:0055085

GO:0071422

GO:0071423

GO:1902356

GO:1902358

HMNXSV003048613

ILMN_1664168

PH_hs_0010878

TC17001035.hg

X66114_rna1_at

g4506996_3p_a_at

Participates

as a component of

SLC25A11 homodimer [mitochondrial inner membrane] (Homo sapiens)

Inferred To

Homologues of SLC25A11 [mitochondrial inner membrane] (Sus scrofa)

slc25a11 [mitochondrial inner membrane] (Danio rerio)

slc25a11 [mitochondrial inner membrane] (Xenopus tropicalis)

Slc25a11 [mitochondrial inner membrane] (Mus musculus)

Slc25a11 [mitochondrial inner membrane] (Rattus norvegicus)

SLC25A11 [mitochondrial inner membrane] (Bos taurus)

SLC25A11 [mitochondrial inner membrane] (Canis familiaris)

SLC25A11 [mitochondrial inner membrane] (Gallus gallus)

SLC25A11 [mitochondrial inner membrane] (Plasmodium falciparum)

SLC25A11 [mitochondrial inner membrane] (Sus scrofa)

misc-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

Dmel\CG1907 [mitochondrial inner membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_003553.2

Guide to Pharmacology - Targets

1053

ENSEMBL

ENST00000225665, ENSP00000225665, ENSP00000440804, ENST00000544061

OpenTargets

ENSG00000108528

HPA

ENSG00000108528-SLC25A11

PRO

Q02978

Pharos - Targets

Q02978

GlyGen

Q02978

Orphanet

SLC25A11

HMDB Protein

HMDBP01116

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	17
UniProt:P12830 CDH1	8	CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-750) [plasma membrane] (R-HSA-202940) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) CDH1(701-882) [extracellular region] (R-HSA-2534158) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(732-882) [plasma membrane] (R-HSA-3827997)	0.556	3
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581)	0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:Q15078 CDK5R1	4	MyrG-CDK5R1(2-307) [plasma membrane] (R-HSA-421083) CDK5R1(99-307) [nucleoplasm] (R-HSA-6805262) CDK5R1(99-307) [cytosol] (R-HSA-8863415) MyrG-CDK5R1(2-98) [plasma membrane] (R-HSA-8863400)	0.556	3
UniProt:Q7KZN9 COX15	1	COX15 [mitochondrial inner membrane] (R-HSA-2995350)	0.527	2
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3

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