Reactome: A Curated Pathway Database

malate + NAD+ <=> oxaloacetate + NADH + H+

Stable Identifier
R-HSA-198508
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
(S)-malate + NAD+ <=> oxaloacetate + NADH + H+
Locations in the PathwayBrowser
Summation

Cytosolic malate dehydrogenase catalyzes the reaction of malate and NAD+ to form oxaloacetate and NADH + H+ (Lo et al. 2005). The dimeric structure of the human dehydrogenase is inferred from that established for its well-studied pig homolog (Birktoft et al. 1989).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
L-malate dehydrogenase activity of malate dehydrogenase 1 dimer [cytosol] malate dehydrogenase 1 dimer [cytosol] L-malate dehydrogenase activity (0030060)
Orthologous Events
Cross References
Rhea