Reactome: A Curated Pathway Database

Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4

Stable Identifier
R-HSA-198513
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
alpha-D-glucose 6-phosphate (cytosol) + orthophosphate (ER lumen) => alpha-D-glucose 6-phosphate (ER lumen) + orthophosphate (cytosol) (SLC37A4)
Locations in the PathwayBrowser
Summation

The SLC37A4 transport protein in the endoplasmic reticulum membrane mediates the exchange of cytosolic glucose-6-phosphate and orthophosphate from the endoplasmic reticulum lumen. Defects in this transporter are associated with glycogen storage disease type Ib (Gerin et al. 1997; Chen et al. 2008; Veiga-da-Cunha et al. 1998).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
glucose 6-phosphate:inorganic phosphate antiporter activity of SLC37A4 [endoplasmic reticulum membrane] SLC37A4 [endoplasmic reticulum membrane] glucose 6-phosphate:inorganic phosphate antiporter activity (0061513)
Orthologous Events