Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4

Stable Identifier
R-HSA-198513
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
alpha-D-glucose 6-phosphate (cytosol) + orthophosphate (ER lumen) => alpha-D-glucose 6-phosphate (ER lumen) + orthophosphate (cytosol) (SLC37A4)
Locations in the PathwayBrowser
Summation

The SLC37A4 transport protein in the endoplasmic reticulum membrane mediates the exchange of cytosolic glucose-6-phosphate and orthophosphate from the endoplasmic reticulum lumen. Defects in this transporter are associated with glycogen storage disease type Ib (Gerin et al. 1997; Chen et al. 2008; Veiga-da-Cunha et al. 1998).

Literature References
PubMed ID Title Journal Year
18337460 The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic

Chen, SY, Pan, CJ, Nandigama, K, Mansfield, BC, Ambudkar, SV, Chou, JY

FASEB J. 2008
9428641 Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib

Gerin, I, Veiga-da-Cunha, M, Achouri, Y, Collet, JF, Van Schaftingen, E

FEBS Lett 1997
9758626 A gene on chromosome 11q23 coding for a putative glucose- 6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic

Veiga-da-Cunha, M, Gerin, I, Chen, Y-T, de Barsy, T, de Lonlay, P, Dionisi-Vici, C, Fenske, CD, Lee, PJ, Leonard, JV, Maire, I, McConkie-Rosell, A, Schweitzer, S, Vikkula, M, Van Schaftingen, E

Am. J. Hum. Genet. 1998
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glucose 6-phosphate:inorganic phosphate antiporter activity of SLC37A4 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed