AKT phosphorylates IKKalpha

Stable Identifier
R-HSA-198611
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AKT mediates IKKalpha (Inhibitor of nuclear factor kappa B kinase subunit alpha) phosphorylation at threonine 23, which is required for NF-kB activation. NF-kB promoted gene transcription enhances neuronal survival.

Literature References
PubMed ID Title Journal Year
10485710 NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

Ozes, ON, Mayo, LD, Gustin, JA, Pfeffer, SR, Pfeffer, LM, Donner, DB

Nature 1999
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created