AKT phosphorylates p21Cip1 and p27Kip1

Stable Identifier
R-HSA-198613
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation of p27Kip1 at T157 and of p21Cip1 at T145 by AKT leads to their retention in the cytoplasm, segregating these cyclin-dependent kinase (CDK) inhibitors from cyclin-CDK complexes.

Literature References
PubMed ID Title Journal Year
12244303 Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

Viglietto, G, Motti, ML, Bruni, P, Melillo, RM, D'Alessio, A, Califano, D, Vinci, F, Chiappetta, G, Tsichlis, P, Bellacosa, A, Fusco, A, Santoro, M

Nat Med 2002
11231573 Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

Zhou, BP, Liao, Y, Xia, W, Spohn, B, Lee, MH, Hung, MC

Nat. Cell Biol. 2001
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Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
Physical Entity
Activity
Orthologous Events
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