Reactome | RICTOR [cytosol]

RICTOR [cytosol]

Stable Identifier

R-HSA-198632

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RICTOR protein, Q8N6M7_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - mTORC2 phosphorylates AKT1 on serine-473 (Homo sapiens)
        
        TORC2 complex [cytosol] (Homo sapiens)
        
        RICTOR [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        TORC2 complex phosphorylates SGK1 (Homo sapiens)
        
        TORC2 complex [cytosol] (Homo sapiens)
        
        RICTOR [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6R327 RICTOR

Gene Names

RICTOR, KIAA1999

Chain

chain:1-1708

Reference Genes

BioGPS Gene:253260 RICTOR

COSMIC (genes):RICTOR RICTOR

CTD Gene:253260 RICTOR

dbSNP Gene:253260 RICTOR

ENSEMBL:ENSG00000164327 RICTOR

ENSEMBL_homo_sapiens_GENE:ENSG00000164327.14 RICTOR

HGNC:28611 RICTOR

KEGG Gene (Homo sapiens):253260 RICTOR

Monarch:253260 RICTOR

NCBI Gene:253260 RICTOR

OMIM:609022 RICTOR

UCSC:Q6R327 RICTOR

Reference Transcript

Other Identifiers

11722098_a_at

11722099_at

11722100_s_at

11746384_s_at

11758472_s_at

16995551

226310_PM_at

226310_at

226312_PM_at

226312_at

228248_PM_at

228248_at

253260

2854240

2854242

2854243

2854244

2854245

2854246

2854247

2854248

2854249

2854250

2854252

2854253

2854254

2854255

2854257

2854258

2854260

2854261

2854262

2854263

2854264

2854265

2854266

2854267

2854268

2854269

2854270

2854271

2854273

2854275

2854276

2854277

2854279

2854285

2854288

2854290

2854293

2854294

2854296

2854300

2854301

2854305

2854320

2854321

56927_at

63010_at

75840_at

8111698

88646_at

A_32_P15017

A_32_P193322

GO:0001932

GO:0001938

GO:0005515

GO:0005794

GO:0005829

GO:0006954

GO:0007010

GO:0007163

GO:0009792

GO:0010468

GO:0012501

GO:0018105

GO:0019901

GO:0023052

GO:0030036

GO:0030307

GO:0030838

GO:0031669

GO:0031929

GO:0031932

GO:0032008

GO:0032956

GO:0033135

GO:0036211

GO:0038203

GO:0042325

GO:0043022

GO:0043066

GO:0043226

GO:0043539

GO:0048856

GO:0050727

GO:0050731

GO:0051896

GO:0051897

GO:0060090

GO:0065003

GO:0098772

GO:2000114

HMNXSV003027810

Hs.109909.0.A1_3p_at

Hs.9343.0.S1_3p_at

Hs.9343.0.S2_3p_at

ILMN_1705828

PH_hs_0041183

TC05001294.hg

Participates

as a component of

TORC2 complex [cytosol] (Homo sapiens)

Inferred To

piaA [cytosol] (Dictyostelium discoideum)

Rictor [cytosol] (Mus musculus)

Rictor [cytosol] (Rattus norvegicus)

rictor [cytosol] (Drosophila melanogaster)

rict-1 [cytosol] (Caenorhabditis elegans)

RICTOR [cytosol] (Canis familiaris)

RICTOR [cytosol] (Gallus gallus)

RICTOR [cytosol] (Sus scrofa)

TSC11 [cytosol] (Saccharomyces cerevisiae)

ste20 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001272369.1, NP_689969.2, NP_001272368.1

OpenTargets

ENSG00000164327

GeneCards

Q6R327

HPA

ENSG00000164327-RICTOR

Ensembl

ENST00000511516, ENSG00000164327, ENST00000357387, ENST00000296782, ENSP00000296782, ENSP00000349959, ENSP00000423019

PRO

Q6R327

Pharos - Targets

Q6R327

PDB

6ZWM, 7TZO, 7PE9, 5ZCS, 7PE8, 6ZWO, 7PE7

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.774	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.774	6
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.706	5
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.659	8
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	4
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.527	2