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RICTOR [cytosol]
Stable Identifier
R-HSA-198632
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RICTOR protein, Q8N6M7_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant is phosphorylated by TORC2 complex (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
RICTOR [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
TORC2 complex phosphorylates SGK1 (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
RICTOR [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
RICTOR [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
RICTOR [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
RICTOR [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6R327 RICTOR
Gene Names
RICTOR, KIAA1999
Chain
chain:1-1708
Reference Genes
BioGPS Gene:253260 RICTOR
COSMIC (genes):RICTOR RICTOR
CTD Gene:253260 RICTOR
dbSNP Gene:253260 RICTOR
ENSEMBL:ENSG00000164327 RICTOR
HGNC:28611 RICTOR
KEGG Gene (Homo sapiens):253260 RICTOR
Monarch:253260 RICTOR
NCBI Gene:253260 RICTOR
OMIM:609022 RICTOR
UCSC:Q6R327 RICTOR
Reference Transcript
RefSeq:NM_001285439.1 RICTOR
RefSeq:NM_001285440.1 RICTOR
RefSeq:NM_152756.4 RICTOR
Other Identifiers
0001400324
11722098_a_at
11722099_at
11722100_s_at
11746384_s_at
11758472_s_at
16995551
226310_at
226312_at
228248_at
253260
2854240
2854242
2854243
2854244
2854245
2854246
2854247
2854248
2854249
2854250
2854252
2854253
2854254
2854255
2854257
2854258
2854260
2854261
2854262
2854263
2854264
2854265
2854266
2854267
2854268
2854269
2854270
2854271
2854273
2854275
2854276
2854277
2854279
2854285
2854288
2854290
2854293
2854294
2854296
2854300
2854301
2854305
2854320
2854321
37802
37803
56927_at
5ZCS
63010_at
75840_at
8111698
88646_at
A_32_P15017
A_32_P193322
AAH51729
AAI37164
AAI37165
AAI44510
AAS79796
AB082530
AC008964
AC109467
AL834497
AY515854
BAC02708
BC051729
BC137163
BC137164
BC144509
CAD39155
CAH18135
CCDS34148
CCDS68861
CH471119
CR749280
D6R9S6
EAW55980
ENSG00000164327
ENSP00000296782
ENSP00000349959
ENSP00000423019
ENST00000296782
ENST00000296782.9
ENST00000357387
ENST00000357387.7
ENST00000511516
ENST00000511516.5
EntrezGene:253260
EntrezGene:RICTOR
GO:0001932
GO:0001938
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0006464
GO:0006950
GO:0007010
GO:0007165
GO:0007275
GO:0008047
GO:0008150
GO:0008283
GO:0009790
GO:0009792
GO:0010468
GO:0016032
GO:0018105
GO:0019899
GO:0019901
GO:0022607
GO:0030010
GO:0030234
GO:0030838
GO:0030950
GO:0031532
GO:0031929
GO:0031932
GO:0032008
GO:0032148
GO:0032956
GO:0032991
GO:0033135
GO:0042325
GO:0043022
GO:0043087
GO:0044403
GO:0048856
GO:0050727
GO:0050731
GO:0051896
GO:0051897
GO:0065003
GO:2000114
HGNC:28611
HPA037802
HPA037803
Hs.109909.0.A1_3p_at
Hs.9343.0.S1_3p_at
Hs.9343.0.S2_3p_at
ILMN_1705828
ILMN_1727171
IPR016024
IPR028267
IPR028268
IPR029259
IPR029451
IPR029452
IPR029453
MIM:609022
NM_001285439
NM_001285440
NM_152756
NP_001272368
NP_001272369
NP_689969
PF14663
PF14664
PF14665
PF14666
PF14668
PH_hs_0041183
RICTOR
RICTOR-201
RICTOR-202
RICTOR-207
SM01303
SM01307
SM01308
SM01309
SM01310
TC05001294.hg
UPI000020C9D4
UPI00003529F3
UPI0000EE67F5
XM_006714463
XM_011514005
XM_011514006
XM_017009311
XM_017009312
XM_017009313
XM_017009314
XM_017009315
XP_006714526
XP_011512307
XP_011512308
XP_016864800
XP_016864801
XP_016864802
XP_016864803
XP_016864804
Participant Of
hasComponent
TORC2 complex [cytosol]
Inferred To
RICTOR [cytosol] (Bos taurus)
RICTOR [cytosol] (Caenorhabditis elegans)
RICTOR [cytosol] (Canis familiaris)
RICTOR [cytosol] (Danio rerio)
RICTOR [cytosol] (Dictyostelium discoideum)
RICTOR [cytosol] (Drosophila melanogaster)
RICTOR [cytosol] (Gallus gallus)
RICTOR [cytosol] (Mus musculus)
RICTOR [cytosol] (Rattus norvegicus)
RICTOR [cytosol] (Saccharomyces cerevisiae)
RICTOR [cytosol] (Schizosaccharomyces pombe)
RICTOR [cytosol] (Sus scrofa)
RICTOR [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001272369.1
,
NP_001272368.1
,
NP_689969.2
OpenTargets
ENSG00000164327
GeneCards
Q6R327
PRO
Q6R327
Orphanet
24860
PDB
5ZCS
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.659
8
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.527
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.527
2
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