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p-S166,S188-MDM2 [cytosol]
Stable Identifier
R-HSA-198638
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S166,188-MDM2, p-MDM2, Phospho-MDM2
Icon
Locations in the PathwayBrowser for interactor UniProt:P62081 RPS7
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant phosphorylates MDM2 (Homo sapiens)
p-S166,S188-MDM2 [cytosol] (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
NPM1-ALK- and PI3K-dependent MDM2 phosphorylation (Homo sapiens)
p-S166,S188-MDM2 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
AKT phosphorylates MDM2 (Homo sapiens)
p-S166,S188-MDM2 [cytosol] (Homo sapiens)
MDM2 translocates to the nucleus (Homo sapiens)
p-S166,S188-MDM2 [cytosol] (Homo sapiens)
SGK1 phosphorylates MDM2 (Homo sapiens)
p-S166,S188-MDM2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the cytosol (Homo sapiens)
AKT phosphorylates MDM2 (Homo sapiens)
p-S166,S188-MDM2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00987 MDM2
Gene Names
MDM2
Chain
chain:1-491
Reference Genes
BioGPS Gene:4193 MDM2
COSMIC (genes):MDM2 MDM2
CTD Gene:4193 MDM2
dbSNP Gene:4193 MDM2
ENSEMBL:ENSG00000135679 MDM2
ENSEMBL_homo_sapiens_GENE:ENSG00000135679.27 MDM2
HGNC:6973 MDM2
KEGG Gene (Homo sapiens):4193 MDM2
Monarch:4193 MDM2
NCBI Gene:4193 MDM2
OMIM:164785 MDM2
UCSC:Q00987 MDM2
Reference Transcript
RefSeq:NM_001278462.1 MDM2
RefSeq:XM_006719399.3 MDM2
RefSeq:NM_002392.5 MDM2
RefSeq:NM_001145339.2 MDM2
RefSeq:XM_005268872.4 MDM2
Other Identifiers
11731564_x_at
11731565_x_at
11731566_a_at
11731567_a_at
11731568_x_at
11753563_x_at
11753688_a_at
11753689_x_at
11753819_a_at
11753820_x_at
11756046_x_at
16753853
1859_s_at
1880_at
2008_s_at
205386_PM_s_at
205386_s_at
211832_PM_s_at
211832_s_at
217373_PM_x_at
217373_x_at
217542_PM_at
217542_at
225160_PM_x_at
225160_x_at
229711_PM_s_at
229711_s_at
238733_PM_at
238733_at
244616_3p_x_at
244616_PM_x_at
244616_x_at
3421301
3421302
3421303
3421304
3421305
3421306
3421307
3421310
3421311
3421315
3421316
3421322
3421323
3421325
3421328
3421329
3421334
3421335
3421336
3421337
3421338
3421339
3421340
3421341
3421342
3421343
3421344
3421345
3421346
3421347
3421348
3421349
3421350
3421351
3421361
38509_at
3979479
4193
46744_s_at
53464_at
61888_at
62280_at
64992_i_at
64993_r_at
75871_at
7956989
A_14_P118388
A_14_P133404
A_14_P135914
A_23_P139895
A_23_P309545
A_23_P502750
A_24_P925664
A_33_P3361707
GE58146
GE832699
GE83502
GO:0000122
GO:0000209
GO:0000278
GO:0001568
GO:0001974
GO:0002027
GO:0002039
GO:0003013
GO:0003170
GO:0003181
GO:0003203
GO:0003281
GO:0003283
GO:0003723
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006511
GO:0006886
GO:0006913
GO:0006915
GO:0006977
GO:0007089
GO:0007507
GO:0008097
GO:0008270
GO:0008284
GO:0009410
GO:0009636
GO:0010039
GO:0010468
GO:0010628
GO:0010629
GO:0010955
GO:0010977
GO:0012501
GO:0016567
GO:0016604
GO:0016740
GO:0016874
GO:0016925
GO:0017053
GO:0019789
GO:0019899
GO:0019904
GO:0023052
GO:0030154
GO:0030163
GO:0030666
GO:0031410
GO:0031625
GO:0031648
GO:0032026
GO:0032436
GO:0032991
GO:0033612
GO:0034504
GO:0036211
GO:0042176
GO:0042220
GO:0042802
GO:0042975
GO:0043021
GO:0043066
GO:0043130
GO:0043161
GO:0043226
GO:0043518
GO:0045184
GO:0045472
GO:0045787
GO:0045892
GO:0045931
GO:0046677
GO:0046827
GO:0046872
GO:0048545
GO:0048856
GO:0048870
GO:0051149
GO:0051603
GO:0051604
GO:0051726
GO:0051865
GO:0060411
GO:0061630
GO:0061663
GO:0065003
GO:0065008
GO:0070301
GO:0071236
GO:0071301
GO:0071310
GO:0071312
GO:0071363
GO:0071375
GO:0071391
GO:0071407
GO:0071456
GO:0071480
GO:0071494
GO:0072537
GO:0072717
GO:0097718
GO:0140096
GO:1901797
GO:1902254
GO:1904404
GO:1904707
GO:1904754
GO:1990000
GO:1990785
HMNXSV003000562
HMNXSV003053865
Hs.116932.0.A1_3p_at
Hs.168732.0.A1_3p_at
Hs.168732.0.A1_3p_x_at
Hs.272346.0.S1_3p_s_at
Hs.332938.1.S1_3p_a_at
Hs.37494.0.A1_3p_at
ILMN_1736829
ILMN_1814208
ILMN_2389851
M92424_at
PH_hs_0023082
TC12000606.hg
TC12002437.hg
U33202_s_at
U33203_s_at
g7230489_3p_s_at
Participates
as an output of
NPM1-ALK- and PI3K-dependent MDM2 phosphorylation (Homo sapiens)
AKT1 E17K mutant phosphorylates MDM2 (Homo sapiens)
AKT phosphorylates MDM2 (Homo sapiens)
SGK1 phosphorylates MDM2 (Homo sapiens)
as an input of
MDM2 translocates to the nucleus (Homo sapiens)
Other forms of this molecule
PolyUb-MDM2 [nucleoplasm]
monoSUMO1-K182-MDM2 [nucleoplasm]
MDM2 [plasma membrane]
MDM2 [endocytic vesicle membrane]
p-5S,T-MDM2 [nucleoplasm]
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
p-S166,S188,T218-MDM2 [nucleoplasm]
MDM2 [nucleoplasm]
MDM2 [cytosol]
p-S166,S188-MDM2 [nucleoplasm]
Inferred To
Homologues of p-S166,S188-MDM2 [cytosol]
(Xenopus tropicalis)
phospho-Mdm2 [cytosol]
(Mus musculus)
phospho-Mdm2 [cytosol]
(Rattus norvegicus)
phospho-MDM2 [cytosol]
(Bos taurus)
phospho-MDM2 [cytosol]
(Canis familiaris)
phospho-MDM2 [cytosol]
(Gallus gallus)
phospho-MDM2 [cytosol]
(Sus scrofa)
phospho-mdm2 [cytosol]
(Danio rerio)
phospho-mdm2 [cytosol]
(Xenopus tropicalis)
phospho-p-S166,S188-MDM2 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 166
Coordinate
166
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 188
Coordinate
188
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001265391.1
,
XP_006719462.1
,
XP_005268929.1
,
NP_002383.2
,
NP_001138811.1
Guide to Pharmacology - Targets
3136
OpenTargets
ENSG00000135679
ZINC - Substances
MDM2_HUMAN
ZINC target
Q00987
PRO
Q00987
PDB
6Q96
,
2C6A
,
4WT2
,
8EI9
,
6YR6
,
3V3B
,
7NA3
,
2F1Y
,
2C6B
,
7AD0
,
4OCC
,
2MPS
,
6T2D
,
3W69
,
8BGU
,
3JZK
,
4JVR
,
5J7G
,
4OGV
,
6AAW
,
6GGN
,
6Q9H
,
5UMM
,
4HG7
,
3TJ2
,
7BIR
,
5Z02
,
5MNJ
,
1T4E
,
2HDP
,
2M86
,
7BMG
,
7BJ0
,
8F0Z
,
4JWR
,
5HMK
,
5WTS
,
7AI0
,
5XXK
,
7BJ6
,
5LAY
,
2VJF
,
4UD7
,
5HMH
,
4JV7
,
4OAS
,
8AEU
,
2GV2
,
1T4F
,
8EIB
,
6SQO
,
3LBL
,
2VJE
,
7QDQ
,
6T2F
,
4ODF
,
3LNJ
,
7KJM
,
6Q9O
,
4ZGK
,
8F10
,
6I3S
,
5ZXF
,
4OGN
,
3JZR
,
4QO4
,
5LAZ
,
7AYE
,
8F13
,
6HFA
,
6H22
,
5LN2
,
4OQ3
,
4ERE
,
5LAV
,
6T2E
,
4HFZ
,
6Q9L
,
4UE1
,
3IWY
,
2AXI
,
3G03
,
2FOP
,
7BIT
,
4JVE
,
3VBG
,
3TPX
,
4ZYI
,
5AFG
,
4OBA
,
4XXB
,
6I29
,
2LZG
,
7BIV
,
5VK0
,
5OAI
,
3IUX
,
4JV9
,
5SWK
,
8P0D
,
5HMI
,
5C5A
,
4UMN
,
5OC8
,
5LAW
,
3EQS
,
4MDN
,
7NA2
,
3TU1
,
4ZYC
,
3LNZ
,
2RUH
,
4ERF
,
8EIA
,
5TRF
,
7NA4
,
4ZFI
,
5J7F
,
4ODE
,
1Z1M
,
7NUS
,
8EIC
,
6IM9
,
3LBK
,
3MQS
,
6KZU
,
1RV1
,
4DIJ
,
3VZV
,
4OGT
,
4QOC
,
4MDQ
,
6Y4Q
,
3JZS
,
8F12
,
4HBM
,
1YCR
,
7AI1
,
4ZYF
,
7NA1
ZINC - Investigational
MDM2_HUMAN
HPA
ENSG00000135679-MDM2
GeneCards
Q00987
Ensembl
ENST00000299252
,
ENST00000539479
,
ENSP00000353611
,
ENST00000360430
,
ENSP00000444430
,
ENST00000258149
,
ENST00000393413
,
ENSP00000258149
,
ENSP00000299252
,
ENSP00000377065
,
ENSG00000135679
Pharos - Targets
Q00987
Orphanet
21735
ZINC - Predictions - Purchasable
MDM2_HUMAN
HMDB Protein
HMDBP02432
Interactors (73)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.995
117
UniProt:Q93009 USP7
2
USP7 [cytosol]
(R-HSA-8853511)
USP7 [nucleoplasm]
(R-HSA-3215278)
0.965
34
UniProt:O15151 MDM4
5
PolyUb-MDM4 [nucleoplasm]
(R-HSA-6782502)
p-S403-MDM4 [nucleoplasm]
(R-HSA-349461)
p-S346,S367,S403-MDM4 [nucleoplasm]
(R-HSA-349441)
PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
(R-HSA-6804938)
MDM4 [nucleoplasm]
(R-HSA-349430)
0.938
15
UniProt:P62913 RPL11
1
RPL11 [cytosol]
(R-HSA-72406)
0.921
13
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.895
18
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.821
6
UniProt:P62081 RPS7
2
RPS7 [nucleoplasm]
(R-HSA-6790635)
RPS7 [cytosol]
(R-HSA-72383)
0.817
17
UniProt:Q8N726 CDKN2A
12
p14ARF [nucleoplasm]
(R-HSA-1629813)
p14ARF [cytosol]
(R-HSA-9645669)
p14ARF [mitochondrial matrix]
(R-HSA-9645695)
p14ARF R98L;R99S [cytosol]
(R-HSA-9645730)
p14ARF R82C [cytosol]
(R-HSA-9645750)
p14ARF R90H [cytosol]
(R-HSA-9645755)
p14ARF R88Q [cytosol]
(R-HSA-9645754)
p14ARF R87C [cytosol]
(R-HSA-9645759)
p14ARF R81G [cytosol]
(R-HSA-9645741)
p14ARF R98Q [cytosol]
(R-HSA-9645757)
p14ARF R99C [cytosol]
(R-HSA-9645756)
p14ARF V22Pfs*46 [cytosol]
(R-HSA-9646285)
0.813
5
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.807
6
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.736
4
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.734
5
UniProt:P49757 NUMB
1
NUMB [plasma membrane]
(R-HSA-443595)
0.718
7
UniProt:P19338 NCL
3
NCL [plasma membrane]
(R-HSA-9836466)
NCL [macropinosome membrane]
(R-HSA-9837666)
NCL [nucleoplasm]
(R-HSA-6791213)
0.71
8
UniProt:P68104 EEF1A1
7
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
0.709
9
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.708
5
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.697
5
UniProt:P23396 RPS3
2
RPS3 [nucleoplasm]
(R-HSA-6798714)
RPS3 [cytosol]
(R-HSA-72369)
0.686
8
UniProt:P46777 RPL5
1
RPL5 [cytosol]
(R-HSA-72482)
0.669
5
UniProt:O96017 CHEK2
3
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
CHEK2 [nucleoplasm]
(R-HSA-113824)
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
0.66
6
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.641
3
UniProt:Q96FW1 OTUB1
2
OTUB1 [cytosol]
(R-HSA-933411)
OTUB1 [nucleoplasm]
(R-HSA-6783242)
0.632
5
UniProt:P29067
3
Arrb2 [endocytic vesicle membrane]
(R-RNO-9910881)
Arrb2 [cytosol]
(R-RNO-6783000)
Arrb2 [cytosol]
(R-RNO-416464)
0.631
4
UniProt:Q9H2X6 HIPK2
3
p-HIPK2 [nucleoplasm]
(R-HSA-6799375)
HIPK2 [nucleoplasm]
(R-HSA-3215222)
monoSUMO1-K32-HIPK2 [nucleoplasm]
(R-HSA-4090405)
0.62
5
UniProt:Q71UM5 RPS27L
2
RPS27L [nucleoplasm]
(R-HSA-6791197)
RPS27L [cytosol]
(R-HSA-8868849)
0.619
6
IntAct:EBI-15762335 PMI
0.618
3
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.616
11
UniProt:P61289 PSME3
1
PSME3 [cytosol]
(R-HSA-68816)
0.612
8
UniProt:P26447 S10A4
0.611
3
UniProt:P48730 CSNK1D
3
CSNK1D [nucleoplasm]
(R-HSA-421305)
CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5685717)
CSNK1D [cytosol]
(R-HSA-380315)
0.61
6
IntAct:EBI-4399559 UBIQ
0.609
2
UniProt:P29590 PML
5
polySUMO3-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000386)
polySUMO2-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000423)
monoSUMO1-K65,160,490-PML [nucleoplasm]
(R-HSA-3000440)
PML [nucleoplasm]
(R-HSA-1031706)
PML [cytosol]
(R-HSA-5624327)
0.609
6
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.602
7
UniProt:P42677 RPS27
2
RPS27 [nucleoplasm]
(R-HSA-6791190)
RPS27 [cytosol]
(R-HSA-72361)
0.602
5
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.591
9
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.589
2
UniProt:P29590-5 PML
0.582
6
UniProt:P62829 RPL23
1
RPL23 [cytosol]
(R-HSA-72430)
0.573
3
UniProt:P42574 CASP3
5
CASP3(1-277) [cytosol]
(R-HSA-57021)
CASP3(29-175) [nucleoplasm]
(R-HSA-211194)
CASP3(176-277) [nucleoplasm]
(R-HSA-211203)
CASP3(29-175) [cytosol]
(R-HSA-141644)
CASP3(176-277) [cytosol]
(R-HSA-141646)
0.571
2
UniProt:O15350 TP73
3
PolyUb-TP73 [cytosol]
(R-HSA-8957256)
TP73 [cytosol]
(R-HSA-8957239)
TP73 [nucleoplasm]
(R-HSA-6798094)
0.558
4
UniProt:P23297 S100A1
1
S100A1 [extracellular region]
(R-HSA-6805991)
0.558
2
UniProt:P29034 S10A2
0.558
2
UniProt:Q13362 PPP2R5C
3
PPP2R5C [nucleoplasm]
(R-HSA-3008946)
p-S337-PPP2R5C [cytosol]
(R-HSA-6811447)
PPP2R5C [cytosol]
(R-HSA-3008954)
0.558
5
UniProt:P06703 S10A6
0.558
2
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.558
2
UniProt:Q9NVN8 GNL3L
0.556
8
UniProt:Q9NZM5 NOP53
0.547
2
UniProt:O15297 PPM1D
1
PPM1D [nucleoplasm]
(R-HSA-2562518)
0.544
4
UniProt:Q9BY89 K1671
0.544
2
UniProt:Q9Y4L5 RNF115
1
RNF115 [cytosol]
(R-HSA-8850904)
0.544
2
UniProt:P08069 IGF1R
3
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.536
2
UniProt:P60866 RPS20
2
RPS20 [nucleoplasm]
(R-HSA-6798727)
RPS20 [cytosol]
(R-HSA-72349)
0.527
2
UniProt:P78352 DLG4
3
DLG4 [cytosol]
(R-HSA-6794267)
DLG4 [endocytic vesicle membrane]
(R-HSA-416847)
DLG4 [plasma membrane]
(R-HSA-202135)
0.525
3
UniProt:P17535 JUND
1
JUND [nucleoplasm]
(R-HSA-9009924)
0.524
3
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.524
4
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.524
3
UniProt:Q2HR73 VIRF4
0.524
2
UniProt:P48729-2 CSNK1A1
0.524
3
UniProt:Q92736 RYR2
1
RYR2 [sarcoplasmic reticulum membrane]
(R-HSA-937283)
0.524
2
UniProt:Q5T7V8 GORAB
0.524
6
UniProt:Q15466 NR0B2
1
NR0B2 [nucleoplasm]
(R-HSA-376312)
0.524
4
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cytosol]
(R-HSA-195263)
CSNK1A1 [cilium]
(R-HSA-5632507)
0.524
3
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.524
3
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.524
3
UniProt:P15311 EZR
3
p-Y146,Y354-EZR [cytosol]
(R-HSA-374572)
p-T567-EZR [cytosol]
(R-HSA-374559)
EZR [cytosol]
(R-HSA-9020826)
0.524
3
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.524
3
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.508
2
UniProt:Q00688 FKBP3
0.508
2
UniProt:Q6PCD5 RFWD3
0.499
2
UniProt:Q9NS23 RASF1
0.499
5
UniProt:Q13362-1 PPP2R5C
0.499
3
UniProt:Q6P5F9 Xpo1
2
Xpo1 [nucleoplasm]
(R-MMU-9769779)
Xpo1 [cytosol]
(R-MMU-165539)
0.499
4
UniProt:P0C6X5-PRO_0000283876 REP
0.463
3
IntAct:EBI-1800051 CDKN1A
0.462
2
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