ERK1/2 activates ELK1

Stable Identifier
R-HSA-198731
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ERK1/2 activates ELK1
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Following translocation to the nucleus, ERK1/2 directly phosphorylates key effectors, including the ubiquitous transcription factors ELK1 (Ets like protein 1). At least five residues in the C terminal domain of ELK1 are phosphorylated upon stimulation with growth factor stimulation. ELK1 can form a ternary complex with the serum response factor (SRF) and consensus sequences, such as serum response elements (SRE), on DNA, thus stimulating transcription of a set of immediate early genes like FOS (c-fos) (Marais et al, 1993; Gille et al, 1995; Duan et al, 1998; reviewed in Treisman, 1995).
Literature References
PubMed ID Title Journal Year
8386592 The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

Treisman, R, Wynne, J, Marais, R

Cell 1993
7588619 Journey to the surface of the cell: Fos regulation and the SRE

Treisman, R

EMBO J. 1995
11145955 Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1

Xie, W, Safe, S, Duan, R, Burghardt, RC

J. Biol. Chem. 2001
7889942 ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

Moomaw, C, Gille, H, Shaw, PE, Cobb, MH, Thomae, O, Slaughter, C, Kortenjann, M

EMBO J 1995
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Catalyst Activity

protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]

Physical Entity
p-T,Y MAPK dimers [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
ERK1/2 activates ELK1 (Mus musculus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
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