ERK1/2 activates ELK1

Stable Identifier
R-HSA-198731
Type
Reaction
Species
Homo sapiens
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Following translocation to the nucleus, ERK1/2 directly phosphorylates key effectors, including the ubiquitous transcription factors ELK1 (Ets like protein 1). At least five residues in the C terminal domain of ELK1 are phosphorylated upon stimulation with growth factor stimulation. ELK1 can form a ternary complex with the serum response factor (SRF) and consensus sequences, such as serum response elements (SRE), on DNA, thus stimulating transcription of a set of immediate early genes like FOS (c-fos) (Marais et al, 1993; Gille et al, 1995; Duan et al, 1998; reviewed in Treisman, 1995).

Literature References
PubMed ID Title Journal Year
7588619 Journey to the surface of the cell: Fos regulation and the SRE

Treisman, R

EMBO J. 1995
8386592 The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

Marais, R, Wynne, J, Treisman, R

Cell 1993
11145955 Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1

Duan, R, Xie, W, Burghardt, RC, Safe, S

J. Biol. Chem. 2001
7889942 ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

Gille, H, Kortenjann, M, Thomae, O, Moomaw, C, Slaughter, C, Cobb, MH, Shaw, PE

EMBO J 1995
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Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]
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