TCR complex interacts with peptide antigen-presenting MHC Class I

Stable Identifier
R-HSA-198955
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

T cells distinguish foreign material from self through presentation of fragments of the antigen by the MHC cell surface receptors. Only if an MHC molecule presents an appropriate antigenic peptide will a cellular immune response be triggered. The orchestration of recognition and signaling events, from the initial recognition of antigenic peptides to the lysis of the target cell, is performed in a localized environment on the T cell, called the immunological synapse, and requires the coordinated activities of several T-Cell Receptor (TCR)-associated molecules. This particular reaction depicts the interaction of the TCR with MHC Class I molecules on somatic cell, requiring the support of CD3 and CD8 proteins.

Literature References
PubMed ID Title Journal Year
16551255 How TCRs bind MHCs, peptides, and coreceptors

Rudolph, MG, Stanfield, RL, Wilson, IA

Annu Rev Immunol 2006
15136729 Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3

Kjer-Nielsen, L, Dunstone, MA, Kostenko, L, Ely, LK, Beddoe, T, Mifsud, NA, Purcell, AW, Brooks, AG, McCluskey, J, Rossjohn, J

Proc Natl Acad Sci U S A 2004
15534202 Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment

Arnett, KL, Harrison, SC, Wiley, DC

Proc Natl Acad Sci U S A 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed