TCR complex interacts with peptide antigen-presenting MHC Class I

Stable Identifier
R-HSA-198955
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

T cells distinguish foreign material from self through presentation of fragments of the antigen by the MHC cell surface receptors. Only if an MHC molecule presents an appropriate antigenic peptide will a cellular immune response be triggered. The orchestration of recognition and signaling events, from the initial recognition of antigenic peptides to the lysis of the target cell, is performed in a localized environment on the T cell, called the immunological synapse, and requires the coordinated activities of several T-Cell Receptor (TCR)-associated molecules. This particular reaction depicts the interaction of the TCR with MHC Class I molecules on somatic cell, requiring the support of CD3 and CD8 proteins.

Participants
Participant Of
Orthologous Events