Expression of CYP1A1

Stable Identifier
R-HSA-1989764
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The CYP1A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein (van der Meer et al. 2010, Rakhshandehroo et al. 2009). The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that controls the expression of a diverse set of genes. AHR acts as a sensor of polyaromatic chemicals, which upon activation, translocates to the nucleus and binds with the aryl hydrocarbon receptor nuclear translocator (ARNT) to transactivate target genes via binding to xenobiotic response elements (XREs) in their promoter regions. AHR targets genes of Phase I and Phase II metabolism, such as cytochrome P450 1A1 (CYP1A1) (Beischlag et al. 2008). AHR is regulated by the aryl hydrocarbon receptor repressor (AHRR, aka BHLHE77, KIAA1234) that inhibits both xenobiotic-induced and constitutively active AHR transcriptional activity in many species (Hahn et al. 2009, Haarmann-Stemmann & Abel 2006).

Literature References
PubMed ID Title Journal Year
20110263 Profiling of promoter occupancy by PPAR{alpha} in human hepatoma cells via ChIP-chip analysis

van der Meer, DL, Degenhardt, T, Vaisanen, S, de Groot, PJ, Heinaniemi, M, de Vries, SC, Muller, M, Carlberg, C, Kersten, S

Nucleic Acids Res 2010
18540824 The aryl hydrocarbon receptor complex and the control of gene expression

Beischlag, TV, Luis Morales, J, Hollingshead, BD, Perdew, GH

Crit. Rev. Eukaryot. Gene Expr. 2008
16972786 The arylhydrocarbon receptor repressor (AhRR): structure, expression, and function

Haarmann-Stemmann, T, Abel, J

Biol. Chem. 2006
19710929 Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human

Rakhshandehroo, M, Hooiveld, G, Muller, M, Kersten, S

PLoS One 2009
18848529 Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor

Hahn, ME, Allan, LL, Sherr, DH

Biochem. Pharmacol. 2009
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