NKG2D homodimer interacting with ligands

Stable Identifier
R-HSA-198983
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NKG2D is an activating immunoreceptor. By engaging NKG2D, HlA Class I-like molecules such as MICA, MICB, ULBP1-4 and RAE-1 provide powerful costimulation for NK cells and T-cells and can determine the magnitude and outcome of certain effector functions. NKG2D ligands are upregulated on the surfaces of cells under conditions of stress, for example infection or tumorigenesis, and therefore act as molecular flags to the immune system that something is wrong.

Literature References
PubMed ID Title Journal Year
11955595 Asymmetric ligand recognition by the activating natural killer cell receptor NKG2D, a symmetric homodimer

Strong, RK

Mol Immunol 2002
16737824 Structural basis for recognition of MHC and MHC-like ligands by natural killer cell receptors

Deng, L, Mariuzza, RA

Semin Immunol 2006
11858820 Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells

Borrego, F, Kabat, J, Kim, DK, Lieto, L, Maasho, K, Pena, J, Solana, R, Coligan, JE

Mol Immunol 2002
Participants
Participant Of
Orthologous Events
Authored
Reviewed