Reactome | MADCAM1-1 binds Integrin alpha4beta7

MADCAM1-1 binds Integrin alpha4beta7

Stable Identifier

R-HSA-199032

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mucosal addressin cell adhesion molecule (MADCAM1) is present in the endothelium of mucosa, and binds alpha-4 beta-7 integrin and L-selectin, regulating both the passage and retention of leukocytes in mucosal tissues. MADCAM1 has been shown to be present as a homodimer.

Literature References

PubMed ID	Title	Journal	Year
11807247	A reassessment of the MAdCAM-1 structure and its role in integrin recognition Dando, J, Wilkinson, KW, Ortlepp, S, King, DJ, Brady, RL	Acta Crystallogr D Biol Crystallogr	2002
9700512	Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses Wang, J, Springer, TA	Immunol Rev	1998