Reactome | MADCAM1-1 binds Integrin alpha4beta7

MADCAM1-1 binds Integrin alpha4beta7

Stable Identifier

R-HSA-199032

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane

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Mucosal addressin cell adhesion molecule (MADCAM1) is present in the endothelium of mucosa, and binds alpha-4 beta-7 integrin and L-selectin, regulating both the passage and retention of leukocytes in mucosal tissues. MADCAM1 has been shown to be present as a homodimer.

Literature References

PubMed ID	Title	Journal	Year
11807247	A reassessment of the MAdCAM-1 structure and its role in integrin recognition Dando, J, Wilkinson, KW, Ortlepp, S, King, DJ, Brady, RL	Acta Crystallogr D Biol Crystallogr	2002
9700512	Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses Wang, J, Springer, TA	Immunol Rev	1998