MADCAM1-1 binds Integrin alpha4beta7

Stable Identifier
R-HSA-199032
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Mucosal addressin cell adhesion molecule (MADCAM1) is present in the endothelium of mucosa, and binds alpha-4 beta-7 integrin and L-selectin, regulating both the passage and retention of leukocytes in mucosal tissues. MADCAM1 has been shown to be present as a homodimer.

Literature References
PubMed ID Title Journal Year
11807247 A reassessment of the MAdCAM-1 structure and its role in integrin recognition

Dando, J, Wilkinson, KW, Ortlepp, S, King, DJ, Brady, RL

Acta Crystallogr D Biol Crystallogr 2002
9700512 Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses

Wang, J, Springer, TA

Immunol Rev 1998
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created