MADCAM1-1 binds Integrin alpha4beta7

Stable Identifier
R-HSA-199032
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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MADCAM1-1 binds Integrin alpha4beta7
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Mucosal addressin cell adhesion molecule (MADCAM1) is present in the endothelium of mucosa, and binds alpha-4 beta-7 integrin and L-selectin, regulating both the passage and retention of leukocytes in mucosal tissues. MADCAM1 has been shown to be present as a homodimer.

Literature References
PubMed ID Title Journal Year
11807247 A reassessment of the MAdCAM-1 structure and its role in integrin recognition

Dando, J, Wilkinson, KW, Ortlepp, S, King, DJ, Brady, RL

Acta Crystallogr D Biol Crystallogr 2002
9700512 Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses

Wang, J, Springer, TA

Immunol Rev 1998
Participants
Input
Output
Participant Of
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Orthologous Events
MADCAM1-1 binds Integrin alpha4beta7 (Bos taurus)
MADCAM1-1 binds Integrin alpha4beta7 (Canis familiaris)
MADCAM1-1 binds Integrin alpha4beta7 (Mus musculus)
MADCAM1-1 binds Integrin alpha4beta7 (Rattus norvegicus)
MADCAM1-1 binds Integrin alpha4beta7 (Sus scrofa)
Authored
de Bono, B  (2007-07-08)
Reviewed
Trowsdale, J  (2007-08-06)
Barrow, AD  (2015-05-13)
Created
de Bono, B  (2007-07-08)
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