Ligands bind L-selectin

Stable Identifier
R-HSA-199046
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

L-selectin plays a major role in leukocyte traffic through lymph node high endothelial venules.

Both MAdCAM and GlyCAM-1 are major L-selectin ligands produced by these venules and mediate leukocyte rolling, particularly in lymphocytes. They are also expressed in mammary tissue and play an important role in the transfer of immune cells into milk secretions.

The adhesive properties of CD34 and its potential role in homing lymphocytes to lymphoid tissues mimics the mechanims leukocytes adopt to travel to inflammatory sites.

Literature References
PubMed ID Title Journal Year
12588680 Expression of potential lymphocyte trafficking mediator molecules in the mammary gland

Nishimura, T

Vet Res 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed