Reactome: A Curated Pathway Database

KLRC1:KLRD1 heterodimer interacts with HLA-E

Stable Identifier
R-HSA-199062
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

After interaction with its ligand HLA-E, which is expressed on normal cells, the C-type lectin inhibitory receptor CD94/NKG2A suppresses activation signaling processes. CD94/NKG2A receptors continuously recycle from the cell surface through endosomal compartments and back again in a process that requires energy and the cytoskeleton. This steady state process appears to be largely unaffected by exposure to ligand.

Literature References
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