CD200 binds to CD200R

Stable Identifier
R-HSA-199154
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

While not ubiquitously distributed, CD200 is expressed on a wide range of cell types including thymocytes, B-cells, activated T-cells, follicular dendritic cells, endothelium, CNS neurons in the central nervous system, cells in reproductive organs, keratinocytes and renal glomeruli. CD200R is a myeloid-inhibitory receptor, despite the absence of classical ITIMs in the cytoplasmic portion of the protein. Interestingly, CD200 is also expressed on neurons within the CNS and would be predicted to modulate activation of microglia through CD200R.

Literature References
PubMed ID Title Journal Year
16928187 Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal?

Minas, K, Liversidge, J

Crit Rev Immunol 2006
15187158 CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules

Gorczynski, R, Chen, Z, Kai, Y, Lee, L, Wong, S, Marsden, PA

J Immunol 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed