MHC Class I interacts with CD160

Stable Identifier
R-HSA-199169
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic NK cells. MHC class I molecules bind to CD160 receptors on circulating NK lymphocytes and this triggers their cytotoxic activity and cytokine production. NK cells stimulated by IL-15 secrete soluble CD160 protein that binds to MHC-I molecules, resulting in the inhibition of the cytotoxic CD8+ T lymphocyte activity and of the CD160-mediated NK cell cytotoxicity.

Literature References
PubMed ID Title Journal Year
16129954 HLA class I/NK cell receptor interaction in early human decidua basalis: possible functional consequences

Rabot, M, Tabiasco, J, Polgar, B, Aguerre-Girr, M, Berrebi, A, Bensussan, A, Strbo, N, Rukavina, D, Le Bouteiller, P

Chem Immunol Allergy 2005
17237375 A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity

Giustiniani, J, Marie-Cardine, A, Bensussan, A

J Immunol 2007
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