Reactome: A Curated Pathway Database

MHC Class I interacts with CD160

Stable Identifier
R-HSA-199169
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic NK cells. MHC class I molecules bind to CD160 receptors on circulating NK lymphocytes and this triggers their cytotoxic activity and cytokine production. NK cells stimulated by IL-15 secrete soluble CD160 protein that binds to MHC-I molecules, resulting in the inhibition of the cytotoxic CD8+ T lymphocyte activity and of the CD160-mediated NK cell cytotoxicity.

Literature References
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Participant Of