SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix

Stable Identifier
R-HSA-199216
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
CoA transport across the inner mitochondrial membrane
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Graves disease carrier protein (SLC25A16), associated with the inner mitochondrial membrane, mediates the transport of cytosolic coenzyme A (CoA-SH) into the mitochondrial matrix. Evidence for this event is indirect. The protein has the sequence motifs expected for a transport protein, and yeast cells deficient in its homologue, Leu5p, fail to accumulate mitochondrial CoA-SH and can be rescued by expression of SLC25A16. At the same time, neither the yeast nor the human protein has been shown directly to function as a transporter (Prohl et al. 2001, Leonardi et al. 2007).

Literature References
PubMed ID Title Journal Year
17242360 Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine

Leonardi, R, Rock, CO, Jackowski, S, Zhang, YM

Proc Natl Acad Sci U S A 2007
11158296 The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix

Prohl, C, Pelzer, W, Diekert, K, Kmita, H, Bedekovics, T, Kispal, G, Lill, R

Mol Cell Biol 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
secondary active transmembrane transporter activity of SLC25A16 [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created