CD40L binds CD40

Stable Identifier
R-HSA-199404
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CD40 is a member of the Tumour Necrosis Factor receptor family and its ligand CD40L is a type II transmembrane protein of the TNF superfamily. The latter is expressed preferentially on T-cells and platelets. In the immune system, CD40-CD40L interaction affects some key processes such as immune cell activation, differentiation, proliferation, and apoptosis. CD40-CD40L interaction also upregulates costimulatory molecules (ICAM-1, VCAM-1, E-selectin, LFA-3, B7.1, B7.2, class II MHC, and CD40 itself).

Literature References
PubMed ID Title Journal Year
16893496 CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system

Chen, K, Huang, J, Gong, W, Zhang, L, Yu, P, Wang, JM

Cell Mol Immunol 2006
Participants
Participant Of
Orthologous Events
Authored
Reviewed