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CD40L binds CD40

Stable Identifier
R-HSA-199404
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CD40 is a member of the Tumour Necrosis Factor receptor family and its ligand CD40L is a type II transmembrane protein of the TNF superfamily. The latter is expressed preferentially on T-cells and platelets. In the immune system, CD40-CD40L interaction affects some key processes such as immune cell activation, differentiation, proliferation, and apoptosis. CD40-CD40L interaction also upregulates costimulatory molecules (ICAM-1, VCAM-1, E-selectin, LFA-3, B7.1, B7.2, class II MHC, and CD40 itself).

Literature References
PubMed ID Title Journal Year
16893496 CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system Cell Mol Immunol 2006
Participants
Participant Of
Orthologous Events