Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Negative regulation of the PI3K/AKT network
Stable Identifier
R-HSA-199418
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
The PI3K/AKT network is negatively regulated by phosphatases that dephosphorylate PIP3, thus hampering AKT activation.
Participants
Events
PTEN dephosphorylates PIP3
(Homo sapiens)
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
(Homo sapiens)
PHLPP dephosphorylates S473 in AKT
(Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
(Homo sapiens)
Participates
as an event of
PIP3 activates AKT signaling (Homo sapiens)
Orthologous Events
Negative regulation of the PI3K/AKT network (Bos taurus)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Canis familiaris)
Negative regulation of the PI3K/AKT network (Danio rerio)
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Gallus gallus)
Negative regulation of the PI3K/AKT network (Mus musculus)
Negative regulation of the PI3K/AKT network (Plasmodium falciparum)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Saccharomyces cerevisiae)
Negative regulation of the PI3K/AKT network (Schizosaccharomyces pombe)
Negative regulation of the PI3K/AKT network (Sus scrofa)
Negative regulation of the PI3K/AKT network (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000652
,
BIOMD0000000648
,
BIOMD0000000655
,
BIOMD0000000883
,
BIOMD0000000654
,
BIOMD0000000424
,
BIOMD0000000653
,
BIOMD0000000468
,
BIOMD0000000651
,
BIOMD0000000255
,
BIOMD0000000656
,
BIOMD0000000175
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Zhao, JJ (2012-08-13)
Yuzugullu, H (2012-08-13)
Thorpe, L (2012-08-13)
Created
Jassal, B (2007-07-10)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text