Reactome: A Curated Pathway Database

PHLPP dephosphorylates S473 in AKT

Stable Identifier
R-HSA-199425
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The PH domain leucine-rich repeat-containing protein phosphatases, PHLPP1 (Gao et al. 2005) and PHLPP2 (Brognard et al. 2007) can specifically dephosphorylate the serine residue and inactivate AKT.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine phosphatase activity of PHLPP (Mn2+ cofactor) [cytosol] PHLPP (Mn2+ cofactor) [cytosol] protein serine/threonine phosphatase activity (0004722)
Orthologous Events