PHLPP dephosphorylates S473 in AKT

Stable Identifier
R-HSA-199425
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PHLPP dephosphorylates S473 in AKT
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The PH domain leucine-rich repeat-containing protein phosphatases, PHLPP1 (Gao et al. 2005) and PHLPP2 (Brognard et al. 2007) can specifically dephosphorylate the serine residue and inactivate AKT.
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Output
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Event Information
Go Biological Process
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (0051898)
Catalyst Activity

protein serine/threonine phosphatase activity of PHLPP (Mn2+ cofactor) [cytosol]

Physical Entity
PHLPP (Mn2+ cofactor) [cytosol] (Homo sapiens)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Orthologous Events
PHLPP dephosphorylates S473 in AKT (Drosophila melanogaster)
PHLPP dephosphorylates S473 in AKT (Gallus gallus)
PHLPP dephosphorylates S473 in AKT (Mus musculus)
PHLPP dephosphorylates S473 in AKT (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Zhao, JJ  (2012-08-13)
Yuzugullu, H  (2012-08-13)
Thorpe, L  (2012-08-13)
Created
Jassal, B  (2007-07-10)
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