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THEM4 [plasma membrane]
Stable Identifier
R-HSA-199437
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
C-terminal modulator protein, Q96KR2_HUMAN, CTMP
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Homo sapiens)
THEM4/TRIB3 [plasma membrane] (Homo sapiens)
THEM4 [plasma membrane] (Homo sapiens)
THEM4/TRIB3 [plasma membrane] (Homo sapiens)
THEM4 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Homo sapiens)
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Homo sapiens)
THEM4/TRIB3 [plasma membrane] (Homo sapiens)
THEM4 [plasma membrane] (Homo sapiens)
THEM4/TRIB3 [plasma membrane] (Homo sapiens)
THEM4 [plasma membrane] (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Homo sapiens)
THEM4/TRIB3 [plasma membrane] (Homo sapiens)
THEM4 [plasma membrane] (Homo sapiens)
THEM4/TRIB3 [plasma membrane] (Homo sapiens)
THEM4 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Homo sapiens)
THEM4/TRIB3 [plasma membrane] (Homo sapiens)
THEM4 [plasma membrane] (Homo sapiens)
THEM4/TRIB3 [plasma membrane] (Homo sapiens)
THEM4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5T1C6 THEM4
Gene Names
THEM4, CTMP
Chain
transit peptide:1-36, chain:37-240
Reference Genes
BioGPS Gene:117145 THEM4
COSMIC (genes):THEM4 THEM4
CTD Gene:117145 THEM4
dbSNP Gene:117145 THEM4
ENSEMBL:ENSG00000159445 THEM4
ENSEMBL_homo_sapiens_GENE:ENSG00000159445.13 THEM4
HGNC:17947 THEM4
KEGG Gene (Homo sapiens):117145 THEM4
Monarch:117145 THEM4
NCBI Gene:117145 THEM4
OMIM:606388 THEM4
UCSC:Q5T1C6 THEM4
Reference Transcript
RefSeq:NM_053055.4 THEM4
Other Identifiers
117145
11743092_at
11758326_s_at
1553118_PM_at
1553118_at
16693259
229253_3p_at
229253_PM_at
229253_at
243492_PM_at
243492_at
2435343
2435344
2435345
2435346
2435348
2435349
2435350
2435351
2435352
2435353
2435354
2435355
2435356
2435357
2435359
2435360
2435368
2435369
2435370
2435376
2435377
2435378
3407914
3407925
3625404
3625405
59980_at
7920114
82092_at
A_24_P928510
A_32_P66674
A_33_P3343432
GE56901
GE86079
GO:0003824
GO:0005515
GO:0005737
GO:0005739
GO:0005743
GO:0005758
GO:0005759
GO:0005829
GO:0005886
GO:0006629
GO:0006631
GO:0006915
GO:0007005
GO:0012501
GO:0016020
GO:0016290
GO:0016787
GO:0023052
GO:0032587
GO:0042995
GO:0043226
GO:0043491
GO:0061024
GO:0102991
GO:1902108
HMNXSV003010692
Hs.266155.0.A1_3p_x_at
Hs2.293691.1.S1_3p_x_at
ILMN_1682120
PH_hs_0029658
PH_hs_0032546
TC01003238.hg
Participates
as a member of
THEM4/TRIB3 [plasma membrane] (Homo sapiens)
Other forms of this molecule
THEM4 [mitochondrial matrix]
THEM4 [cytosol]
Inferred To
THEM4 [plasma membrane]
(Bos taurus)
THEM4 [plasma membrane]
(Canis familiaris)
THEM4 [plasma membrane]
(Dictyostelium discoideum)
THEM4 [plasma membrane]
(Gallus gallus)
THEM4 [plasma membrane]
(Mus musculus)
THEM4 [plasma membrane]
(Rattus norvegicus)
LOC101735170 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_444283.2
OpenTargets
ENSG00000159445
IntEnz
3.1.2.2
HPA
ENSG00000159445-THEM4
GeneCards
Q5T1C6
Ensembl
ENSG00000159445
,
ENSP00000357804
,
ENST00000368814
PRO
Q5T1C6
Pharos - Targets
Q5T1C6
PDB
4AE8
,
4GAH
HMDB Protein
HMDBP11976
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.734
4
UniProt:P16284 PECAM1
5
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
0.556
3
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.556
3
UniProt:P13196 ALAS1
2
PXLP-ALAS1 [mitochondrial matrix]
(R-HSA-1022086)
ALAS1 [mitochondrial matrix]
(R-HSA-189438)
0.527
2
UniProt:P11182 DBT
11
DBT [cytosol]
(R-HSA-9714663)
I98M Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865057)
Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-70017)
Isobutyryl-lipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859151)
Isovaleryl-lipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859144)
2-Methylbutyryl-lipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859145)
LipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859167)
DBT [mitochondrial matrix]
(R-HSA-6792584)
P276C Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865046)
S399C Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865036)
K313_Y338del Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865051)
0.527
2
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