Reactome | THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation

THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation

Stable Identifier

R-HSA-199443

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation

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The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12791994	TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver Kulkarni, RN, Herzig, S, Du, K, Montminy, M	Science	2003
11598301	Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane Kaech, S, Maira, SM, Brazil, DP, Galetic, I, Ingley, E, Thelen, M, Hemmings, BA	Science	2001