THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation

Stable Identifier
R-HSA-199443
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).

Literature References
PubMed ID Title Journal Year
11598301 Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

Maira, SM, Galetic, I, Brazil, DP, Kaech, S, Ingley, E, Thelen, M, Hemmings, BA

Science 2001
12791994 TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

Du, K, Herzig, S, Kulkarni, RN, Montminy, M

Science 2003
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed