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AKT:PIP3:THEM4/TRIB3 [plasma membrane]
Stable Identifier
R-HSA-199453
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Homo sapiens)
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
AKT:PIP3:THEM4/TRIB3 [plasma membrane] (Homo sapiens)
Participants
components
AKT:PIP3 [plasma membrane]
(Homo sapiens)
THEM4/TRIB3 [plasma membrane]
(Homo sapiens)
Participates
as an output of
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Homo sapiens)
This entity regulates
Negatively
TORC2 (mTOR) phosphorylates AKT at S473
(Homo sapiens)
Inferred To
AKT:PIP3:THEM4/TRIB3 [plasma membrane]
(Caenorhabditis elegans)
AKT:PIP3:THEM4/TRIB3 [plasma membrane]
(Danio rerio)
AKT:PIP3:THEM4/TRIB3 [plasma membrane]
(Dictyostelium discoideum)
AKT:PIP3:THEM4/TRIB3 [plasma membrane]
(Drosophila melanogaster)
AKT:PIP3:THEM4/TRIB3 [plasma membrane]
(Gallus gallus)
AKT:PIP3:THEM4/TRIB3 [plasma membrane]
(Mus musculus)
AKT:PIP3:THEM4/TRIB3 [plasma membrane]
(Rattus norvegicus)
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