Reactome: A Curated Pathway Database

C3d-complexed antigen binds to complement receptor

Stable Identifier
R-HSA-199518
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CD19 is a lymphocyte cell surface molecule that functions as a general response regulator or rheostat, which defnes signalling thresholds. These responses are infuenced by signals transduced through a CD19-CD21 cell surface receptor complex, where the binding of complement C3d to CD21 links humoral immune responses with the innate immune system. The CD19-CD21 complex is composed of at least four non-covalently associated proteins: CD19, CD21(complement receptor 2),CD81 and CD225.

Literature References
Participants
Participant Of
Orthologous Events