Reactome | C3d-complexed antigen binds to complement receptor

C3d-complexed antigen binds to complement receptor

Stable Identifier

R-HSA-199518

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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C3d-complexed antigen binds to complement receptor

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CD19 is a lymphocyte cell surface molecule that functions as a general response regulator or rheostat, which defnes signalling thresholds. These responses are infuenced by signals transduced through a CD19-CD21 cell surface receptor complex, where the binding of complement C3d to CD21 links humoral immune responses with the innate immune system. The CD19-CD21 complex is composed of at least four non-covalently associated proteins: CD19, CD21(complement receptor 2),CD81 and CD225.

Literature References

PubMed ID	Title	Journal	Year
17337780	Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity Ross, TM, Toapanta, FR	Immunol Res	2006
15778510	CD19 function in central and peripheral B-cell development Rickert, RC, Kolla, RV, Del Nagro, CJ, Anzelon, AN, Otero, DC, Omori, SA	Immunol Res	2005
14719373	Signaling by the CD19/CD21 complex on B cells Barrington, RA, Carter, RH	Curr Dir Autoimmun	2004