C3d-complexed antigen binds to complement receptor

Stable Identifier
R-HSA-199518
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CD19 is a lymphocyte cell surface molecule that functions as a general response regulator or rheostat, which defnes signalling thresholds. These responses are infuenced by signals transduced through a CD19-CD21 cell surface receptor complex, where the binding of complement C3d to CD21 links humoral immune responses with the innate immune system. The CD19-CD21 complex is composed of at least four non-covalently associated proteins: CD19, CD21(complement receptor 2),CD81 and CD225.

Literature References
PubMed ID Title Journal Year
15778510 CD19 function in central and peripheral B-cell development

Del Nagro, CJ, Otero, DC, Anzelon, AN, Omori, SA, Kolla, RV, Rickert, RC

Immunol Res 2005
17337780 Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity

Toapanta, FR, Ross, TM

Immunol Res 2006
14719373 Signaling by the CD19/CD21 complex on B cells

Carter, RH, Barrington, RA

Curr Dir Autoimmun 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed