Reactome | KIR2DL1 [plasma membrane]

KIR2DL1 [plasma membrane]

Stable Identifier

R-HSA-199538

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Killer cell immunoglobulin-like receptor 2DL1 precursor, K2L1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q06124

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External Reference Information

External Reference

UniProt:P43626 KIR2DL1

Gene Names

KIR2DL1, CD158A, NKAT1

Chain

signal peptide:1-21, chain:22-348

Reference Genes

BioGPS Gene:3802 KIR2DL1

COSMIC (genes):KIR2DL1 KIR2DL1

CTD Gene:3802 KIR2DL1

dbSNP Gene:3802 KIR2DL1

ENSEMBL:ENSG00000125498 KIR2DL1

ENSEMBL_homo_sapiens_GENE:ENSG00000125498.20 KIR2DL1

ENSEMBL_homo_sapiens_GENE:ENSG00000273794.4 KIR2DL1

ENSEMBL_homo_sapiens_GENE:ENSG00000276625.4 KIR2DL1

ENSEMBL_homo_sapiens_GENE:ENSG00000277833.4 KIR2DL1

ENSEMBL_homo_sapiens_GENE:ENSG00000278495.4 KIR2DL1

ENSEMBL_homo_sapiens_GENE:ENSG00000278738.5 KIR2DL1

ENSEMBL_homo_sapiens_GENE:ENSG00000278821.4 KIR2DL1

HGNC:6329 KIR2DL1

KEGG Gene (Homo sapiens):3802 KIR2DL1

Monarch:3802 KIR2DL1

NCBI Gene:3802 KIR2DL1

OMIM:604936 KIR2DL1

UCSC:P43626 KIR2DL1

Reference Transcript

RefSeq:NM_014218.2 KIR2DL1

Other Identifiers

11741900_x_at

11742301_x_at

11761946_at

11761947_x_at

16865484

208179_PM_x_at

208179_x_at

210890_x_at

3802

3841708

3841717

3841721

3841723

3841725

3841730

3841731

3841732

3841740

3841742

3841746

3841749

3841753

3841755

3841758

3841760

3841763

3841764

3841765

3841766

3841767

3841768

3841769

3841770

3841772

3841773

3841774

3841775

3841782

3841785

3841809

3841811

3841814

3841818

3841824

3841829

3841830

3841836

3841841

3841845

3841846

3841847

3841848

3841851

4052951

4052958

4052960

4052965

4052968

4052970

4052971

4052973

4052974

4052975

4052976

4052992

4052996

4052997

4052998

4052999

4053005

4053009

4053021

4053022

4053025

4053045

4053046

4053048

4053049

4053050

4053058

4053061

4053063

4053065

4053067

4053068

4053075

4053079

8031277

8031293

8031297

8031358

8039829

8039842

8039896

A_23_P50571

A_33_P3313920

GO:0002376

GO:0002769

GO:0005515

GO:0005886

GO:0006955

GO:0016020

GO:0023052

GO:0038023

GO:0060089

HMNXSV003004247

HMNXSV003012127

ILMN_1678882

ILMN_1722506

ILMN_1786810

PH_hs_0036459

PH_hs_0036998

PH_hs_0038235

PH_hs_0038457

TC19002659.hg

g1217724_3p_x_at

g2760896_3p_x_at

g897908_3p_x_at

Participates

as a component of

HLA-C group 2 interacting with KIR2DL1 [plasma membrane] (Homo sapiens)

as an input of

KIR2DL1 interacting with HLA-C group 2 (Cw3) (Homo sapiens)

Inferred To

KIR2DL1 [plasma membrane] (Bos taurus)

KIR2DL1 [plasma membrane] (Sus scrofa)

KIR2DL1 [plasma membrane] (Xenopus tropicalis)

KIR3DL2 [plasma membrane] (Bos taurus)

Homologues of KIR2DL2 [plasma membrane] (Bos taurus)

Homologues of KIR2DL2 [plasma membrane] (Mus musculus)

Kir3dl2 [plasma membrane] (Mus musculus)

KIR2DS1 [plasma membrane] (Bos taurus)

Homologues of KIR2DL1 [plasma membrane] (Xenopus tropicalis)

Kir3dl1 [plasma membrane] (Mus musculus)

Kir3dl1 [plasma membrane] (Rattus norvegicus)

LOC100852061 [plasma membrane] (Bos taurus)

KIR3DL1 [plasma membrane] (Bos taurus)

KIR2DL2 [plasma membrane] (Bos taurus)

KIR3DS1 [plasma membrane] (Bos taurus)

Cross References

RefSeq

NP_055033.2

OpenTargets

ENSG00000125498

HPA

ENSG00000125498-KIR2DL1

GeneCards

P43626

Ensembl

ENSP00000482120, ENST00000620449, ENSG00000125498, ENSG00000276625, ENST00000615920, ENSG00000278738, ENST00000611611, ENSP00000478232, ENSP00000484559, ENSG00000277833, ENSP00000478263, ENSP00000479363, ENST00000618563, ENSG00000278821, ENSG00000273794, ENSP00000484361, ENST00000617376, ENSP00000291633, ENSG00000278495, ENST00000622463, ENST00000291633

PRO

P43626

Pharos - Targets

P43626

PDB

1NKR, 1IM9

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10321 HLA-C	8	HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane] (R-HSA-1236799) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236760) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane] (R-HSA-8863915) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [Golgi membrane] (R-HSA-983387) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983354) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [secretory granule membrane] (R-HSA-6803292) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (R-HSA-199595) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983044)	0.792	15
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.488	2
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.488	2
UniProt:P29350 PTPN6	5	PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.462	4

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