Reactome | p-T233-NCF2 [phagolysosome]

p-T233-NCF2 [phagolysosome]

Stable Identifier

R-HSA-1996211

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

phagolysosome

Synonyms

p-T233-p67phox, Neutrophil cytosol factor 2, NCF2_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
15591124	Protein kinase Cdelta regulates p67phox phosphorylation in human monocytes Bhattacharjee, A, Feldman, GM, Wientjes, FB, Oldfield, CM, Zhao, X, Xu, B, Cathcart, MK	J Leukoc Biol	2005

External Reference Information

External Reference

UniProt:P19878 NCF2

Gene Names

NCF2, NOXA2, P67PHOX

Chain

chain:1-526

Reference Genes

BioGPS Gene:4688 NCF2

COSMIC (genes):NCF2 NCF2

CTD Gene:4688 NCF2

dbSNP Gene:4688 NCF2

ENSEMBL:ENSG00000116701 NCF2

HGNC:7661 NCF2

KEGG:hsa:4688 NCF2

Monarch:4688 NCF2

NCBI Gene:4688 NCF2

OMIM:608515 NCF2

UCSC:P19878 NCF2

Reference Transcript

Other Identifiers

11741153_a_at

16697095

209949_PM_at

209949_at

2447415

2447416

2447417

2447418

2447419

2447420

2447421

2447422

2447425

2447426

2447427

2447428

2447429

2447430

2447431

2447432

2447435

2447439

2447441

2447442

2447443

2447445

2447446

2447447

2447448

41038_at

4688

7922773

A_23_P138194

GE57931

GO:0001669

GO:0002376

GO:0003824

GO:0005515

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005886

GO:0006801

GO:0006909

GO:0006968

GO:0009055

GO:0016020

GO:0016175

GO:0016176

GO:0016192

GO:0016491

GO:0031267

GO:0031410

GO:0032010

GO:0042554

GO:0043020

GO:0043226

GO:0045087

GO:0045730

GO:0098542

GO:0098772

HMNXSV003013570

ILMN_1796642

M32011_at

PH_hs_0000123

TC01003616.hg

g12804408_3p_at

Participates

as a component of

NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

NCF2 [cytosol]

Inferred To

phospho-p-T233-NCF2 [phagolysosome] (Gallus gallus)

phospho-Ncf2 [phagolysosome] (Mus musculus)

phospho-Ncf2 [phagolysosome] (Rattus norvegicus)

phospho-ncf2 [phagolysosome] (Danio rerio)

phospho-ncf2 [phagolysosome] (Xenopus tropicalis)

phospho-NCF2 [phagolysosome] (Bos taurus)

phospho-NCF2 [phagolysosome] (Canis familiaris)

phospho-NCF2 [phagolysosome] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 233

Coordinate

233

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_011507883.1, NP_001177723.1, XP_011507882.1, NP_001177718.1, NP_001121123.1, NP_000424.2

OpenTargets

ENSG00000116701

ENSEMBL

ENSP00000407217, ENST00000413720, ENST00000697330, ENSP00000513258, ENSP00000399294, ENST00000367536, ENST00000418089, ENSP00000356505, ENST00000367535, ENSP00000356506

HPA

ENSG00000116701-NCF2

PRO

P19878

Pharos - Targets

P19878

Orphanet

NCF2

PDB

8WEJ, 1WM5, 1K4U, 1HH8, 2DMO, 1E96, 1OEY

HMDB Protein

HMDBP01614

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92845 KIFAP3	3	KIFAP3 [cytosol] (R-HSA-984736) KIFAP3 [cilium] (R-HSA-5624882) KIFAP3 [ciliary tip] (R-HSA-5625382)	0.926	14
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.805	9
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.676	3
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.658	3
UniProt:Q05655 PRKCD	12	PRKCD [cytosol] (R-HSA-58200) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD(330-676) [cytosol] (R-HSA-212551) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) p-T507-PRKCD [cytosol] (R-HSA-5218746) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-676) [nucleoplasm] (R-HSA-450606)	0.544	3
UniProt:P27870 Vav1	5	p-Y-Vav1 [cytosol] (R-MMU-9029091) phospho-Vav1 [plasma membrane] (R-MMU-389323) phospho-Vav1 [cytosol] (R-MMU-437946) Vav1 [cytosol] (R-MMU-434625) Vav1 [plasma membrane] (R-MMU-1045153)	0.524	4