p-6Y-EGFR D770_N771insNPG [plasma membrane]

Stable Identifier
R-HSA-1996335
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Phosphorylated Epidermal Growth Factor Receptor D770_N771insNPG, p-6Y-EGFR Asp770_Asn771insAsnProGly
Icon
p-6Y-EGFR D770_N771insNPG [plasma membrane] icon
p-6Y-EGFR D770_N771insNPG [plasma membrane] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
24353160 Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer

Yasuda, H, Park, E, Yun, CH, Sng, NJ, Lucena-Araujo, AR, Yeo, WL, Huberman, MS, Cohen, DW, Nakayama, S, Ishioka, K, Yamaguchi, N, Hanna, M, Oxnard, GR, Lathan, CS, Moran, T, Sequist, LV, Chaft, JE, Riely, GJ, Arcila, ME, Soo, RA, Meyerson, M, Eck, MJ, Kobayashi, SS, Costa, DB

Sci Transl Med 2013
External Reference Information
External Reference
UniProt:P00533 EGFR
Gene Names
EGFR, ERBB, ERBB1, HER1
Chain
signal peptide:1-24, chain:25-1210
Reference Genes
BioGPS Gene:1956 EGFR
COSMIC (genes):EGFR EGFR
CTD Gene:1956 EGFR
dbSNP Gene:1956 EGFR
ENSEMBL:ENSG00000146648 EGFR
HGNC:3236 EGFR
KEGG:hsa:1956 EGFR
Monarch:1956 EGFR
NCBI Gene:1956 EGFR
OMIM:131550 EGFR
UCSC:P00533 EGFR
Reference Transcript
Participates
as a candidate of
Other forms of this molecule
p-5Y-EGFRvIII [plasma membrane]
EGFRvIII [plasma membrane]
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
p-6Y-EGFR L858R;T790M [plasma membrane]
p-6Y-EGFR A767_V769dup [plasma membrane]
p-6Y-EGFR N771_H773dup [plasma membrane]
p-6Y-EGFR K739_I744dup [plasma membrane]
p-6Y-EGFR E746_A750del [plasma membrane]
p-6Y-EGFR L858R [plasma membrane]
p-6Y-EGFR G719S [plasma membrane]
p-6Y-EGFR L747_P753delinsS [plasma membrane]
p-6Y-EGFR L747_A750delinsP [plasma membrane]
p-6Y-EGFR L747_T751del [plasma membrane]
p-6Y-EGFR L747_S752del [plasma membrane]
p-6Y-EGFR L747_T751delinsP [plasma membrane]
p-6Y-EGFR E746_T751delinsA [plasma membrane]
p-6Y-EGFR E746_S752delinsV [plasma membrane]
p-6Y-EGFR L861Q [plasma membrane]
p-6Y-EGFR A289V [plasma membrane]
p-6Y-EGFR T263P [plasma membrane]
p-6Y-EGFR G598V [plasma membrane]
p-6Y-EGFR R108K [plasma membrane]
p-6Y-EGFR A289T [plasma membrane]
p-6Y-EGFR G719C [plasma membrane]
p-6Y-EGFR A289D [plasma membrane]
p-6Y-EGFR G719A [plasma membrane]
EGFR L858R;T790M [plasma membrane]
EGFR E746_A750del;T790M [plasma membrane]
EGFR D770_N771insNPG [plasma membrane]
EGFR K739_I744dup [plasma membrane]
EGFR A767_V769dup [plasma membrane]
EGFR N771_H773dup [plasma membrane]
EGFR L858R [plasma membrane]
EGFR G719S [plasma membrane]
p-6Y-EGFR [plasma membrane]
EGFR [plasma membrane]
p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane]
EGFR [endosome membrane]
p-4Y-EGFR [plasma membrane]
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
EGFR L747_S752del [plasma membrane]
EGFR G598V [plasma membrane]
EGFR T263P [plasma membrane]
EGFR G719C [plasma membrane]
EGFR E746_S752delinsV [plasma membrane]
EGFR A289T [plasma membrane]
EGFR G719A [plasma membrane]
EGFR E746_T751delinsA [plasma membrane]
EGFR L747_A750delinsP [plasma membrane]
EGFR R108K [plasma membrane]
EGFR L861Q [plasma membrane]
EGFR A289D [plasma membrane]
EGFR L747_T751del [plasma membrane]
EGFR L747_T751delinsP [plasma membrane]
EGFR A289V [plasma membrane]
EGFR L747_P753delinsS [plasma membrane]
EGFR E746_A750del [plasma membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at 1069
Coordinate
1069
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1092
Coordinate
1092
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1110
Coordinate
1110
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1172
Coordinate
1172
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1197
Coordinate
1197
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1016
Coordinate
1016
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
Replacement of residues 770 to 771 by DNPGN
Disease
Name Identifier Synonyms
lung cancer DOID:1324
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
Mondo
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
5XDK, 6JRJ, 7ZYN, 9FRD, 6V66, 8WD4, 8F1Z, 9EWT, 2ITP, 1Z9I, 8GK5, 8UKW, 3OP0, 7ZYM, 7JXK, 4KRL, 7UKW, 5WB8, 7T4J, 5HCZ, 8HV7, 9D3W, 5HG5, 2J5E, 2ITX, 5X27, 5D41, 8PO4, 3G5Y, 6JX4, 3W2R, 8HGS, 7OXB, 6V5P, 6TFV, 3G5V, 6B3S, 4I23, 5UWD, 4LL0, 2GS2, 5JEB, 4LQM, 4ZJV, 6LUD, 9FQS, 7U99, 7KY0, 2GS7, 4JQ7, 2M20, 5EDQ, 4JR3, 6P1D, 2RGP, 8F1H, 7JXL, 5FED, 5XWD, 5HIC, 4KRO, 8DSW, 6V6K, 5CNO, 5X2A, 3VJN, 2M0B, 5ZWJ, 5YU9, 5HG7, 6TG0, 4RIY, 5LV6, 3W33, 6WA2, 6TG1, 3LZB, 5UGA, 7ER2, 7LGS, 4R3R, 3W2O, 5EM6, 9GC4, 5CAL, 3W2S, 5J9Y, 8H7X, 4ZSE, 8G63, 8HV1, 6S89, 8D76, 8F1W, 5FEQ, 4LI5, 4G5P, 7A6I, 3POZ, 1YY9, 3GT8, 7JXI, 5CAP, 3BEL, 8GB4, 5HG9, 2ITZ, 2RF9, 6JXT, 2KS1, 7SYE, 4WD5, 6D8E, 4RJ6, 5CNN, 6Z4B, 2ITW, 6V6O, 8A27, 6ARU, 6WXN, 7U9A, 5CAS, 5UGC, 3W2P, 7K1H, 5EM5, 7ZYP, 2ITT, 6DUK, 2N5S, 5GTY, 7LFS, 9FQP, 8PNZ, 3B2U, 2GS6, 8TJL, 7U98, 8KFQ, 5EDP, 1IVO, 8F1X, 7B85, 8D73, 3QWQ, 6Z4D, 5HG8, 5X2C, 3OB2, 4RJ7, 5C8K, 8HVA, 5HIB, 4KRP, 4I1Z, 6LUB, 4I24, 6S8A, 5CZI, 8PO1, 4LRM, 5EM8, 3NJP, 8FV3, 5CAV, 2EB3, 7ZYQ, 4WRG, 8UKX, 5J9Z, 6VHN, 7LFR, 4R5S, 5XGN, 4KRM, 2ITO, 6P1L, 8A2D, 5CAO, 7JXP, 5WB7, 9HBO, 4UIP, 5UG8, 6S9C, 5C8M, 7SYD, 7A6K, 7AEI, 2ITV, 6S9D, 8HV4, 2RFE, 9H46, 5X2F, 7VRE, 3IKA, 4HJO, 7OM4, 8TO3, 7LEN, 5EM7, 5CAU, 6TFU, 5SX5, 7LG8, 3BUO, 6JRK, 4JRV, 7A2A, 1MOX, 6JZ0, 5CAQ, 4UV7, 4JQ8, 8A2A, 5HCY, 7JXM, 6XL4, 8HGO, 5GMP, 8S1M, 5Y9T, 2ITY, 4RJ4, 6WAK, 2JIV, 9GDV, 6S9B, 5EDR, 8HV5, 8HV8, 2ITU, 3W2Q, 2RFD, 3P0Y, 6P8Q, 7LTX, 4RIW, 5CZH, 3VRR, 4I20, 4I21, 8PO2, 5ZTO, 6TFW, 4TKS, 1XKK, 5SX4, 2EB2, 4ZAU, 4WKQ, 2ITQ, 5GTZ, 5GNK, 8HY7, 4G5J, 7SZ1, 8HGP, 7UKV, 7JXQ, 3VJO, 2ITN, 1M14, 3B2V, 5HCX, 8F1Y, 5X28, 2JIU, 6V5N, 7A6J, 8HV9, 7KXZ, 3UG1, 2J5F, 7SZ0, 8HV2, 7VRA, 3W32, 8EME, 7K1I, 6JWL, 6TFY, 6VHP, 9GC5, 4RJ8, 5X2K, 5C8N, 5UG9, 8PO0, 5Y25, 5XDL, 8UKV, 3PFV, 8SC7, 1NQL, 6JRX, 2J6M, 7AEM, 9EWS, 5CAN, 3GOP, 5FEE, 5XGM, 7JXW, 6VH4, 5U8L, 8A2B, 7T4I, 2JIT, 7SZ7, 3UG2, 8HV3, 7SI1, 7TVD, 8HV6, 9D3V, 7SZ5, 3C09, 4RJ5, 8FV4, 4RIX, 3VRP, 6JX0, 8TO4, 9GC6, 5UGB, 1M17, 4R3P, 4I22, 5X26, 8PO3, 6TFZ
ZINC - Investigational
ZINC - Metabolites
GeneCards
HPA
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (342)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P62993 GRB2  1 0.983 59
 UniProt:P00533 EGFR  20 0.983 31
 UniProt:P29353 SHC1  5 0.976 44
 UniProt:P01133 EGF  5 0.973 29
 UniProt:P22681 CBL  20 0.964 26
 UniProt:P04626 ERBB2  20 0.954 25
 UniProt:Q9UJM3 ERRFI      0.927 16
 UniProt:P21860 ERBB3      0.925 15
 UniProt:P40763 STAT3  12 0.925 16
 UniProt:P12931 SRC  6 0.91 10
 UniProt:P18031 PTPN1  2 0.898 9
 UniProt:P08238 HSP90AB1  6 0.89 10
 UniProt:Q06124 PTPN11  4 0.859 10
 UniProt:P27348 YWHAQ  1 0.854 7
 UniProt:P19174 PLCG1  6 0.85 6
 UniProt:P16885 PLCG2  8 0.838 7
 UniProt:P31947 SFN  1 0.833 9
 UniProt:P62158 CALM      0.828 6
 UniProt:Q96CW1 AP2M1  6 0.828 8
 UniProt:P07900 HSP90AA1  8 0.824 8
 UniProt:P16333 NCK1  2 0.823 6
 UniProt:P07948 LYN  7 0.82 7
 UniProt:P15941 MUC1  19 0.819 6
 UniProt:Q03135 CAV1  5 0.813 7
 UniProt:O00750 PIK3C2B  1 0.811 10
 UniProt:P27986 PIK3R1  16 0.81 7
 UniProt:Q9UBN7 HDAC6  4 0.809 12
 UniProt:Q05209 PTPN12  2 0.807 5
 UniProt:P11142 HSPA8  10 0.803 7
 UniProt:P20417  2 0.802 11
 UniProt:P08581 MET  7 0.8 8
 UniProt:P08107 HSP71      0.799 6
 UniProt:Q92625 ANS1A      0.793 7
 UniProt:Q16543 CDC37  1 0.786 13
 UniProt:P04406 GAPDH  1 0.785 7
 UniProt:P10599 TXN  4 0.785 5
 UniProt:P01135 TGFA  5 0.779 4
 UniProt:P42224 STAT1  8 0.774 7
 UniProt:Q9NRF2 SH2B1  1 0.773 4
 UniProt:P63104 YWHAZ  2 0.772 6
 UniProt:P04083 ANXA1  2 0.772 5
 UniProt:Q92569 PIK3R3  2 0.76 7
 UniProt:O00459 PIK3R2  3 0.76 5
 UniProt:P46109 CRKL  2 0.749 5
 UniProt:Q71U36 TUBA1A  9 0.745 4
 UniProt:Q05397 PTK2  11 0.745 7
 UniProt:P38646 HSPA9  6 0.745 5
 UniProt:O60716 CTNND1  2 0.745 5
 UniProt:P26447 S10A4      0.743 6
 UniProt:Q96JA1 LRIG1  2 0.743 6
 UniProt:Q92870 APBB2      0.737 7
 UniProt:Q9NSE2 CISH  1 0.737 4
 UniProt:Q13480 GAB1  4 0.735 5
 UniProt:P12830 CDH1  20 0.735 4
 UniProt:Q9UQB8 BAIAP2  1 0.735 4
 UniProt:P35221 CTNNA1  2 0.732 6
 UniProt:Q13322 GRB10  2 0.729 4
 UniProt:Q9UNE7 STUB1  1 0.721 4
 UniProt:Q12929 EPS8  1 0.713 4
 UniProt:Q9P0L0 VAPA  4 0.713 4
 UniProt:Q14457 BECN1  4 0.709 8
 UniProt:Q96B97 SH3KBP1  3 0.695 4
 UniProt:Q13387 JIP2      0.692 5
 UniProt:P23467 PTPRB  3 0.692 3
 UniProt:P42684 ABL2  1 0.692 9
 UniProt:P43403 ZAP70  3 0.692 3
 UniProt:Q13239 SLA  1 0.692 3
 UniProt:P51451 BLK  2 0.692 3
 UniProt:P00519 ABL1  6 0.692 3
 UniProt:P46108 CRK  1 0.692 4
 UniProt:Q8TF42 UBS3B      0.69 7
 UniProt:Q14318 FKBP8  2 0.683 4
 UniProt:Q68CZ2 TNS3  1 0.683 5
 UniProt:P16234 PDGFRA  20 0.683 4
 UniProt:O75368 SH3L1      0.681 3
 UniProt:Q8WUM4 PDCD6IP  1 0.681 4
 UniProt:Q99962 SH3GL2  4 0.681 4
 UniProt:O60603 TLR2  3 0.681 3
 UniProt:P41240 CSK  2 0.681 3
 UniProt:Q9UKV8 AGO2  2 0.679 11
 UniProt:O95782 AP2A1  5 0.671 6
 UniProt:O14965 AURKA  6 0.671 5
 UniProt:Q9UQC2 GAB2  5 0.669 3
 UniProt:Q07889 SOS1  3 0.669 3
 UniProt:P34932 HSPA4  2 0.668 3
 UniProt:P23528 CFL1  3 0.668 3
 UniProt:Q09666 AHNK      0.667 4
 UniProt:P51636 CAV2  2 0.667 3
 UniProt:P06493 CDK1  11 0.667 3
 UniProt:Q9NZM3 ITSN2  1 0.653 3
 UniProt:Q15750 TAB1  6 0.653 3
 UniProt:Q9UPY6 WASF3  3 0.653 3
 UniProt:P17174 GOT1  1 0.653 3
 UniProt:P14923 JUP  7 0.653 3
 UniProt:Q16620 NTRK2  6 0.653 3
 UniProt:P31749 AKT1  14 0.653 4
 UniProt:P49407 ARRB1  6 0.653 3
 UniProt:P15311 EZR  3 0.653 3
 UniProt:P04049 RAF1  20 0.653 3
 UniProt:P08631 HCK  2 0.653 3
 UniProt:P32121 ARRB2  3 0.653 3
 UniProt:Q92622 RUBIC      0.65 4
 UniProt:Q15303 ERBB4      0.65 4
 UniProt:Q10567 AP1B1  5 0.649 4
 UniProt:Q8NBJ4 GOLM1  2 0.644 13
 UniProt:P08195 SLC3A2  1 0.643 5
 UniProt:P16615 ATP2A2  2 0.643 3
 UniProt:P60520 GABARAPL2  3 0.635 3
 UniProt:P04150 NR3C1  3 0.635 3
 UniProt:Q9Y2H9 MAST1      0.635 3
 UniProt:Q12933 TRAF2  5 0.635 4
 UniProt:P49069 CAMLG  1 0.635 3
 UniProt:O43561 LAT  3 0.635 3
 UniProt:Q6S5L8 SHC4      0.635 3
 UniProt:Q8WUI4 HDAC7  1 0.635 3
 UniProt:O75791 GRAP2  1 0.635 3
 UniProt:Q02952 AKAP12  1 0.635 3
 UniProt:Q9BRG2 SH23A      0.635 3
 UniProt:P09936 UCHL1  1 0.635 3
 UniProt:Q13094 LCP2  2 0.635 3
 UniProt:Q14247 CTTN  2 0.635 4
 UniProt:P31948 STIP1  1 0.635 3
 UniProt:Q9Y2R2 PTPN22  1 0.635 3
 UniProt:P09769 FGR  3 0.635 3
 UniProt:P18433 PTPRA  1 0.635 3
 UniProt:P17252 PRKCA  8 0.635 3
 UniProt:P42229 STAT5A  4 0.635 4
 UniProt:P46940 IQGAP1  3 0.626 4
 UniProt:Q13438 OS9  1 0.623 3
 UniProt:Q12852 M3K12      0.621 3
 UniProt:Q6UW88 EPGN  2 0.618 3
 UniProt:O14944 EREG  2 0.618 3
 UniProt:Q9NS73 MBIP  1 0.618 3
 UniProt:P04792 HSPB1  3 0.615 3
 UniProt:Q99075 HBEGF  8 0.609 3
 UniProt:Q9BXW9 FANCD2  3 0.604 3
 UniProt:Q9UJ41 RABGEF1  2 0.599 4
 UniProt:Q86VI4 LAP4B      0.599 10
 UniProt:P60033 CD81  1 0.597 6
 UniProt:P08575 PTPRC  2 0.592 2
 UniProt:P14174 MIF  3 0.591 3
 UniProt:Q8IZW8 TNS4  1 0.59 2
 UniProt:O75886 STAM2  2 0.583 3
 UniProt:P07355 ANXA2  6 0.583 4
 UniProt:P29353-7 SHC1      0.581 4
 UniProt:P30530 AXL  3 0.577 5
 UniProt:Q01973 ROR1  2 0.576 8
 UniProt:P23470 PTPRG      0.573 3
 UniProt:Q9Y6R0 NUMBL      0.571 2
 UniProt:P07992 ERCC1  2 0.571 21
 UniProt:P43405 SYK  6 0.571 7
 UniProt:P49757 NUMB  1 0.571 2
 UniProt:Q13882 PTK6  5 0.571 2
 UniProt:Q9UKG1 APPL1  1 0.571 3
 UniProt:P63010 AP2B1  4 0.569 5
 UniProt:P53680 AP2S1  4 0.569 3
 UniProt:O94973 AP2A2  6 0.569 4
 UniProt:hspa1a_hspa1b_human-1 EBI-11820565      0.569 3
 UniProt:Q9UBS4 DNAJB11  1 0.569 3
 UniProt:Q13451 FKBP5  2 0.564 2
 UniProt:P62994 Grb2  3 0.564 5
 UniProt:P07947 YES1  2 0.564 3
 UniProt:Q8IZV2 CKLF8      0.556 3
 UniProt:O75674 TM1L1      0.556 6
 UniProt:Q05513 PRKCZ  5 0.553 2
 UniProt:P14625 HSP90B1  4 0.553 2
 UniProt:P05107 ITGB2  4 0.553 2
 UniProt:P40925 MDH1  1 0.553 2
 UniProt:Q99608 NDN  1 0.553 2
 UniProt:Q9H299 SH3L3      0.553 2
 UniProt:Q8N111 CEND      0.553 2
 UniProt:Q59GR8 Q59GR8      0.553 2
 UniProt:Q14204 DYNC1H1  3 0.553 2
 UniProt:Q99704 DOK1  2 0.553 2
 UniProt:P16930 FAH  1 0.553 2
 UniProt:Q59G22 Q59G22      0.553 2
 UniProt:Q13491 GPM6B      0.553 2
 UniProt:A4FU49 SH321      0.553 2
 UniProt:P60174 TPI1  1 0.553 2
 UniProt:O95433 AHSA1      0.553 2
 UniProt:Q06830 PRDX1  4 0.553 2
 UniProt:Q7L273 KCTD9      0.553 2
 UniProt:Q4KWH8 PLCH1  1 0.553 2
 UniProt:O15511 ARPC5  4 0.553 2
 UniProt:O14544 SOCS6  1 0.553 2
 UniProt:Q99759 MAP3K3  1 0.553 2
 UniProt:P31321 PRKAR1B  2 0.553 2
 UniProt:P19438 TNFRSF1A  2 0.553 2
 UniProt:Q16186 ADRM1  2 0.553 2
 UniProt:P06132 UROD  1 0.553 2
 UniProt:P04075 ALDOA  6 0.553 2
 UniProt:Q8TDI0 CHD5      0.553 2
 UniProt:Q8N2Y8 RUSC2      0.553 2
 UniProt:Q13561 DCTN2  1 0.553 2
 UniProt:Q53GZ6 Q53GZ6      0.553 2
 UniProt:P17600 SYN1  2 0.553 2
 UniProt:P31939 ATIC  5 0.553 2
 UniProt:P54368 OAZ1  1 0.553 2
 UniProt:Q9NNZ3 DNJC4      0.553 2
 UniProt:Q9Y5X1 SNX9  3 0.553 2
 UniProt:Q14050 COL9A3  20 0.553 2
 UniProt:O94992 HEXI1      0.553 2
 UniProt:Q9Y3A3 PHOCN      0.553 2
 UniProt:O94875 SRBS2      0.553 2
 UniProt:Q15819 UBE2V2  2 0.553 2
 UniProt:P45984 MAPK9  3 0.553 2
 UniProt:P45983 MAPK8  3 0.553 2
 UniProt:Q6UWJ1 TMCO3      0.553 2
 UniProt:Q99784 NOE1      0.553 2
 UniProt:Q92918 M4K1      0.553 2
 UniProt:Q07890 SOS2  1 0.553 2
 UniProt:P49798 RGS4  1 0.553 2
 UniProt:O75095 MEGF6      0.553 2
 UniProt:Q15120 PDK3  1 0.553 2
 UniProt:O43707 ACTN4  3 0.553 2
 UniProt:Q8N5H7 SH2D3      0.553 2
 UniProt:Q02297 NRG1  1 0.553 2
 UniProt:P62330 ARF6  2 0.553 2
 UniProt:Q15005 SPCS2  1 0.553 2
 UniProt:Q92733 PRCC  1 0.553 2
 UniProt:Q59EJ3 Q59EJ3      0.553 2
 UniProt:P43243 MATR3      0.553 2
 UniProt:P49908 SELENOP  2 0.553 2
 UniProt:Q8TDB4 HUMMR      0.553 2
 UniProt:Q02156 PRKCE  2 0.553 2
 UniProt:Q9Y237 PIN4      0.553 2
 UniProt:P20336 RAB3A  9 0.553 2
 UniProt:P16152 CBR1  1 0.553 2
 UniProt:P31946 YWHAB  1 0.553 2
 UniProt:O14543 SOCS3  1 0.553 2
 UniProt:Q9Y6K9 IKBKG  12 0.553 2
 UniProt:Q08881 ITK  3 0.553 2
 UniProt:P52306 RAP1GDS1  1 0.553 2
 UniProt:P06396 GSN  7 0.553 2
 UniProt:P60880 SNAP25  7 0.553 2
 UniProt:P11309 PIM1  2 0.553 2
 UniProt:P37840 SNCA  5 0.553 2
 UniProt:P42685 FRK  4 0.553 2
 UniProt:P30307 CDC25C  8 0.553 2
 UniProt:Q9UGK3 STAP2  2 0.553 2
 UniProt:P15498 VAV1  5 0.553 2
 UniProt:O00170 AIP  2 0.553 2
 UniProt:O00401 WASL  4 0.553 2
 UniProt:O14818 PSMA7  2 0.553 2
 UniProt:Q99963 SH3GL3  1 0.553 2
 UniProt:Q13153 PAK1  5 0.553 2
 UniProt:Q07954 LRP1  2 0.553 2
 UniProt:Q14155 ARHGEF7  1 0.553 2
 UniProt:P07949 RET  2 0.553 2
 UniProt:O43639 NCK2  1 0.553 2
 UniProt:Q02790 FKBP4  3 0.553 2
 UniProt:Q9H6Q3 SLA2  1 0.553 2
 UniProt:P52630 STAT2  4 0.553 2
 UniProt:P55036 PSMD4  1 0.553 2
 UniProt:Q96AD5 PNPLA2  4 0.553 2
 UniProt:P26641 EEF1G  3 0.553 2
 UniProt:Q13905 RAPGEF1  2 0.553 2
 UniProt:P05067 APP  20 0.553 2
 UniProt:P21291 CSRP1  1 0.553 2
 UniProt:P53041 PPP5C  2 0.553 2
 UniProt:Q02246 CNTN2  1 0.553 2
 UniProt:P41222 PTGDS  1 0.553 2
 UniProt:Q99952 PTPN18  2 0.553 2
 UniProt:P10636 MAPT  3 0.553 2
 UniProt:P10586 PTPRF  2 0.547 2
 UniProt:P29350 PTPN6  5 0.547 2
 UniProt:P23468 PTPRD  1 0.547 2
 UniProt:Q14956-1 GPNMB      0.544 2
 UniProt:P07948-1 LYN      0.544 2
 UniProt:Q38SD2 LRRK1      0.544 2
 UniProt:P17936 IGFBP3  15 0.539 3
 UniProt:P0DTC2 S  20 0.537 4
 UniProt:O14964 HGS  2 0.536 2
 UniProt:P03372 ESR1  10 0.536 3
 UniProt:P68366 TUBA4A  9 0.527 2
 UniProt:P55060 XPO2      0.527 2
 UniProt:Q6XE38 SG1D4      0.527 2
 UniProt:Q00325 S25A3      0.527 3
 UniProt:O60884 DNAJA2  1 0.527 2
 UniProt:O00483 NDUFA4  1 0.527 2
 UniProt:Q9UK22 FBXO2  1 0.527 3
 UniProt:P31943 HNRNPH1  2 0.527 2
 UniProt:Q8WXA2 PATE1      0.527 2
 UniProt:Q96ER3 SAAL1      0.527 2
 UniProt:Q969Z0 TBRG4  1 0.527 3
 UniProt:Q9H0D6 XRN2  2 0.527 5
 UniProt:Q9Y4L1 HYOU1  3 0.527 2
 UniProt:P40855 PEX19  1 0.527 2
 UniProt:O43592 XPOT  2 0.527 2
 UniProt:P11021 HSPA5  7 0.527 5
 UniProt:P62161 CALM      0.524 6
 UniProt:P03372-4 ESR1  4 0.524 4
 UniProt:Q15109 AGER  1 0.524 2
 UniProt:P13866 SLC5A1  8 0.524 3
 UniProt:Q14956 GPNMB  2 0.524 3
 UniProt:Q00597 FANCC  2 0.519 2
 UniProt:P97313  4 0.518 4
 UniProt:Q9Y6A5 TACC3  1 0.508 3
 UniProt:P46108-1 CRK      0.508 3
 UniProt:Q9BRK4 LZTS2      0.508 2
 UniProt:P49418 AMPH  1 0.508 2
 UniProt:Q8WXI2 CNKSR2  1 0.508 2
 UniProt:Q9HD43 PTPRH      0.508 3
 UniProt:O75563 SKAP2  1 0.508 2
 UniProt:Q7L591 DOK3  3 0.508 2
 UniProt:P35813 PPM1A  2 0.508 2
 UniProt:Q8TEY7 USP33  1 0.508 2
 UniProt:P61619 SEC61A1  2 0.499 2
 IntAct:EBI-4399559 UBIQ      0.499 3
 UniProt:Q80U62 RUBIC      0.499 2
 UniProt:Q9QZC5  1 0.499 7
 UniProt:Q13885 TUBB2A  6 0.499 2
 UniProt:P47869 GABRA2  1 0.499 2
 UniProt:Q92731 ESR2  5 0.499 8
 UniProt:P22682 Cbl  8 0.499 2
 UniProt:Q9UBV2 SEL1L  1 0.499 2
 UniProt:Q96A65 EXOC4  2 0.499 2
 UniProt:Q99959 PKP2  2 0.483 3
 UniProt:P29317 EPHA2  2 0.483 3
 UniProt:Q15208 STK38  1 0.483 2
 UniProt:P13569 CFTR  17 0.483 11
 UniProt:P62841 RPS15  2 0.483 2
 UniProt:Q8IXB1 DNAJC10  1 0.483 3
 UniProt:P10412 H1-4  1 0.483 2
 UniProt:P18074 ERCC2  2 0.483 2
 UniProt:Q9NXR7 BABAM2  2 0.483 2
 UniProt:P17844 DDX5  4 0.483 2
 UniProt:P40238 MPL  1 0.483 2
 UniProt:P78527 PRKDC  4 0.483 2
 UniProt:O14980 XPO1  2 0.483 2
 UniProt:P06576 ATP5F1B  6 0.483 2
 UniProt:P06748 NPM1  11 0.483 5
 UniProt:P35222 CTNNB1  20 0.483 2
 UniProt:Q92598 HSPH1  3 0.471 2
 UniProt:Q9Y6Q6-2 TNFRSF11A      0.463 3
 UniProt:Q13671 RIN1  1 0.463 3
 UniProt:O94898 LRIG2      0.463 4
 UniProt:P0A0I7 AGRA      0.463 2
 UniProt:P46934 NEDD4  1 0.463 3
 UniProt:O43752 STX6  2 0.463 3
 UniProt:Q9UPT5 EXOC7  2 0.463 2
 UniProt:P25098 GRK2  4 0.463 3
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