AKT can phosphorylate RSK

Stable Identifier
R-HSA-199839
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
AKT can phosphorylate RSK
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Ribosomal protein S6 kinase beta-2 (RSK) activation is a highly conserved mitogenic response, and the activities of RSK are stimulated by multiple serine/threonine phosphorylations by different upstream kinases, one of which is AKT.

Literature References
PubMed ID Title Journal Year
10490848 Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt

Kim, JW, Kim, J, Lee, B, Chung, J, Koh, H, Kim, D, Yun, YH, Choi, HS, Jee, K

Oncogene 1999
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
protein kinase B signaling (0043491)
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]

Physical Entity
p-T,p-S-AKT [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AKT can phosphorylate RSK (Caenorhabditis elegans)
AKT can phosphorylate RSK (Canis familiaris)
AKT can phosphorylate RSK (Drosophila melanogaster)
AKT can phosphorylate RSK (Gallus gallus)
AKT can phosphorylate RSK (Mus musculus)
AKT can phosphorylate RSK (Rattus norvegicus)
AKT can phosphorylate RSK (Saccharomyces cerevisiae)
AKT can phosphorylate RSK (Schizosaccharomyces pombe)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-07-12)
Cite Us!