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p-S351-NR4A1 [nucleoplasm]
Stable Identifier
R-HSA-199846
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Phospho-Orphan nuclear receptor NR4A1, NR41_HUMAN, NR4A1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant phosphorylates NR4A1 (NUR77) (Homo sapiens)
p-S351-NR4A1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the nucleus (Homo sapiens)
AKT can phosphorylate NR4A1 (NUR77) (Homo sapiens)
p-S351-NR4A1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22736 NR4A1
Gene Names
NR4A1, GFRP1, HMR, NAK1
Chain
chain:1-598
Reference Genes
COSMIC (genes):NR4A1 NR4A1
dbSNP Gene:3164 NR4A1
ENSEMBL:ENSG00000123358 NR4A1
Participates
as an output of
AKT1 E17K mutant phosphorylates NR4A1 (NUR77) (Homo sapiens)
AKT can phosphorylate NR4A1 (NUR77) (Homo sapiens)
Other forms of this molecule
NR4A1 [nucleoplasm]
Inferred To
phospho-nhr-6 [nucleoplasm]
(Caenorhabditis elegans)
phospho-NR4A1 [nucleoplasm]
(Bos taurus)
phospho-NR4A1 [nucleoplasm]
(Canis familiaris)
phospho-NR4A1 [nucleoplasm]
(Sus scrofa)
phospho-nr4a1 [nucleoplasm]
(Danio rerio)
phospho-nr4a1 [nucleoplasm]
(Xenopus tropicalis)
phospho-Hr38 [nucleoplasm]
(Drosophila melanogaster)
phospho-p-S351-NR4A1 [nucleoplasm]
(Gallus gallus)
phospho-Nr4a1 [nucleoplasm]
(Mus musculus)
phospho-Nr4a1 [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 351
Coordinate
351
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.674
7
UniProt:P55273 CDKN2D
1
CDKN2D [cytosol]
(R-HSA-182580)
0.666
4
IntAct:EBI-20568042 NURRE
0.645
5
UniProt:Q99873 PRMT1
2
PRMT1 [nucleoplasm]
(R-HSA-3215140)
PRMT1 [cytosol]
(R-HSA-9632173)
0.623
6
UniProt:P40305-2 IFI27
0.61
8
UniProt:P32189 GK
1
GK [cytosol]
(R-HSA-55717)
0.581
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.581
6
UniProt:Q17RB8 LONRF1
1
LONRF1 [cytosol]
(R-HSA-8850905)
0.556
3
UniProt:P60370 KRTAP10-5
1
KRTAP10-5 [cytosol]
(R-HSA-6810260)
0.556
3
UniProt:Q96JS3 PGBD1
0.556
3
IntAct:EBI-10173330 386677
0.556
3
UniProt:Q13162 PRDX4
3
PRDX4 [ficolin-1-rich granule lumen]
(R-HSA-6803286)
PRDX4 [extracellular region]
(R-HSA-6806512)
PRDX4 [secretory granule lumen]
(R-HSA-6803305)
0.553
2
UniProt:P03120 VE2
0.553
3
UniProt:Q709F0 ACAD11
1
ACAD11 [mitochondrial inner membrane]
(R-HSA-5695987)
0.527
2
UniProt:Q504T8 MIDN
0.527
2
UniProt:O60888 CUTA
0.524
2
UniProt:P04350 TUBB4A
6
TUBB4A folding intermediate [cytosol]
(R-HSA-392789)
TUBB4A unfolded [cytosol]
(R-HSA-392778)
Polyglycyl-TUBB4A [cytosol]
(R-HSA-8867397)
Polyglutamyl-TUBB4A [cytosol]
(R-HSA-8867425)
TUBB4A [axonemal microtubule]
(R-HSA-5610435)
TUBB4A [cytosol]
(R-HSA-190588)
0.524
2
UniProt:Q9P2G1 AKIB1
0.524
2
UniProt:P50552 VASP
1
VASP [cytosol]
(R-HSA-446323)
0.524
2
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.508
3
UniProt:Q9Y4D7 PLXND1
1
PLXND1 [plasma membrane]
(R-HSA-209637)
0.508
2
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