AKT can phosphorylate NR4A1 (NUR77)

Stable Identifier
R-HSA-199863
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AKT inhibits DNA binding of NUR77 and inhibits its pro-apoptotic function (PMID 11438550). However, the relevance of AKT for NUR77 phosphorylation has recently been questioned: according to recent work, NUR77 is phosphorylated by RSK (and MSK) rather than by AKT (PMID 16223362).

Literature References
PubMed ID Title Journal Year
11274386 Akt phosphorylates and regulates the orphan nuclear receptor Nur77

Pekarsky, Y, Hallas, C, Palamarchuk, A, Koval, A, Bullrich, F, Hirata, Y, Bichi, R, Letofsky, J, Croce, CM

Proc Natl Acad Sci U S A 2001
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Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
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