MAPKAPK2 phosphorylates CREB at Serine 133

Stable Identifier
R-HSA-199917
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

p38 MAPK activation leads to CREB Serine 133 phosphorylation through the activation of MAPKAP kinase 2 or the closely related MAPKAP kinase 3.

Literature References
PubMed ID Title Journal Year
7551568 Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals

Bonni, A, Ginty, DD, Dudek, H, Greenberg, ME

Mol. Cell. Neurosci. 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T222,S272-MAPKAPK2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created