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ERK5 activates the transcription factor MEF2
Stable Identifier
R-HSA-199929
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
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The MEF2 (Myocyte-specific enhancer factor 2) proteins constitute a family of transcription factors: MEF2A, MEF2B, MEF2C, and MEF2D. MEF2A and MEF2C are known substrates of ERK5, and their transactivating activity can be stimulated by ERK5 via direct phosphorylation. MEF2A and MEF2C are expressed in developing and adult brain including cortex and cerebellum.
Participants
Input
ATP [nucleoplasm]
MEF2 [nucleoplasm]
(Homo sapiens)
Output
ADP [nucleoplasm]
p-MEF2 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
ERK/MAPK targets (Homo sapiens)
Catalyst Activity
protein serine/threonine kinase activity of p-T218,Y220-MAPK7 [nucleoplasm]
Physical Entity
p-T218,Y221-MAPK7 [nucleoplasm]
(Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
ERK5 activates the transcription factor MEF2 (Rattus norvegicus)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
Jassal, B (2007-07-13)
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