Reactome | COPE [cytosol]

COPE [cytosol]

Stable Identifier

R-HSA-199969

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Coatomer epsilon subunit

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
        
        Active ARF recruits coatomer (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
      - ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
      - Active ARF recruits coatomer (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
        
        Active ARF recruits coatomer to the Golgi (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)
        
        COPI vesicle uncoating at the ER (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPE [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14579 COPE

Gene Names

COPE

Chain

initiator methionine:, chain:2-308

Reference Genes

BioGPS Gene:11316 COPE

COSMIC (genes):COPE COPE

CTD Gene:11316 COPE

dbSNP Gene:11316 COPE

ENSEMBL:ENSG00000105669 COPE

ENSEMBL_homo_sapiens_GENE:ENSG00000105669.14 COPE

HGNC:2234 COPE

KEGG Gene (Homo sapiens):11316 COPE

Monarch:11316 COPE

NCBI Gene:11316 COPE

OMIM:606942 COPE

UCSC:O14579 COPE

Reference Transcript

Other Identifiers

11316

11737073_a_at

11737074_x_at

11741238_a_at

11741239_x_at

16870493

201264_PM_at

201264_at

3855325

3855326

3855328

3855330

3855334

3855335

3855337

3855338

3855343

3855344

3855352

3855354

3855356

3855357

38647_at

8035553

A_23_P209088

A_24_P399622

GE55214

GO:0000139

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006888

GO:0006890

GO:0006891

GO:0015031

GO:0016020

GO:0016192

GO:0030126

GO:0030133

GO:0030137

GO:0030663

GO:0031410

GO:0043226

GO:0099612

HMNXSV003042948

ILMN_1738103

ILMN_2339627

PH_hs_0001051

TC19002690.hg

g6005734_3p_at

g6005734_3p_x_at

Participates

as a component of

trimeric coatomer complex [cytosol] (Homo sapiens)

Other forms of this molecule

COPE [endoplasmic reticulum membrane]

COPE [Golgi membrane]

COPE [transport vesicle]

Inferred To

Cope [cytosol] (Mus musculus)

Cope [cytosol] (Rattus norvegicus)

epsilonCOP [cytosol] (Drosophila melanogaster)

sec28 [cytosol] (Schizosaccharomyces pombe)

COPE [cytosol] (Bos taurus)

COPE [cytosol] (Canis familiaris)

COPE [cytosol] (Gallus gallus)

COPE [cytosol] (Plasmodium falciparum)

COPE [cytosol] (Sus scrofa)

cope [cytosol] (Danio rerio)

cope [cytosol] (Dictyostelium discoideum)

cope [cytosol] (Xenopus tropicalis)

SEC28 [cytosol] (Saccharomyces cerevisiae)

cope-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_955476.1, NP_009194.2, NP_955474.1

OpenTargets

ENSG00000105669

HPA

ENSG00000105669-COPE

GeneCards

O14579

Ensembl

ENST00000262812, ENST00000351079, ENSG00000105669, ENSP00000343134, ENST00000349893, ENSP00000262812, ENSP00000345674

PRO

O14579

Pharos - Targets

O14579

HMDB Protein

HMDBP08333

PDB

6TZT, 6U3V

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.643	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	11
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.527	2
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.483	3