ER to Golgi Anterograde Transport

Stable Identifier
R-HSA-199977
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
Click the image above or here to open this pathway in the Pathway Browser

Secretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing. About 25% of the proteome may be exported from the ER in human cells. This cargo is recognized and concentrated into COPII vesicles, which range in size from 60-90 nm, and move cargo from the ER to the ERGIC. Soluble cargo in the ER lumen is concentrated into COPII vesicles through interaction with a receptor with the receptor subsequently recycled to the ER in COPI vesicles through retrograde traffic. The ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites. Retrograde traffic makes use of microtubule-directed COPI-coated vesicles, carrying ER proteins and membrane back to the ER.

Literature References
PubMed ID Title Journal Year
11252894 Three ways to make a vesicle

Kirchhausen, Tomas

Nat Rev Mol Cell Biol 2000
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created