Reactome | COPA [cytosol]

COPA [cytosol]

Stable Identifier

R-HSA-199978

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Coatomer alpha subunit

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
        
        Active ARF recruits coatomer (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
      - ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
      - Active ARF recruits coatomer (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
        
        Active ARF recruits coatomer to the Golgi (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)
        
        COPI vesicle uncoating at the ER (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53621 COPA

Gene Names

COPA

Chain

chain:1-1224, peptide:1-35, peptide:1-25

Reference Genes

BioGPS Gene:1314 COPA

COSMIC (genes):COPA COPA

CTD Gene:1314 COPA

dbSNP Gene:1314 COPA

ENSEMBL:ENSG00000122218 COPA

ENSEMBL_homo_sapiens_GENE:ENSG00000122218.17 COPA

HGNC:2230 COPA

KEGG Gene (Homo sapiens):1314 COPA

Monarch:1314 COPA

NCBI Gene:1314 COPA

OMIM:601924 COPA

UCSC:P53621 COPA

Reference Transcript

Other Identifiers

11732125_s_at

11751927_x_at

1314

16695345

208684_PM_at

208684_at

214336_PM_s_at

214336_s_at

2440144

2440145

2440146

2440147

2440148

2440149

2440151

2440153

2440154

2440155

2440156

2440157

2440158

2440159

2440162

2440164

2440165

2440167

2440169

2440170

2440172

2440173

2440174

2440180

2440181

2440183

2440185

2440186

2440193

2440195

2440198

2440199

2440200

2440206

2440207

2440210

2440216

2440220

2440221

2440227

2440229

2440231

2440232

36962_at

45020_r_at

7921583

A_23_P325932

A_24_P28367

A_32_P20454

GE58333

GO:0000139

GO:0005179

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006886

GO:0006888

GO:0006890

GO:0006891

GO:0007165

GO:0015031

GO:0016020

GO:0016192

GO:0022600

GO:0023052

GO:0030117

GO:0030126

GO:0030133

GO:0030157

GO:0030426

GO:0030663

GO:0031410

GO:0043226

GO:0048018

GO:0070062

GO:0098772

HMNXSV003001860

Hs.75887.1.A1_3p_a_at

ILMN_1811615

PH_hs_0026462

PH_hs_0031935

TC01003400.hg

U24105_at

g1638873_3p_x_at

Participates

as a component of

trimeric coatomer complex [cytosol] (Homo sapiens)

Other forms of this molecule

COPA [endoplasmic reticulum membrane]

COPA [Golgi membrane]

COPA [transport vesicle]

Inferred To

Copa [cytosol] (Mus musculus)

Copa [cytosol] (Rattus norvegicus)

alphaCOP [cytosol] (Drosophila melanogaster)

COP1 [cytosol] (Saccharomyces cerevisiae)

copa [cytosol] (Danio rerio)

copa [cytosol] (Dictyostelium discoideum)

copa [cytosol] (Xenopus tropicalis)

COPA [cytosol] (Bos taurus)

COPA [cytosol] (Canis familiaris)

COPA [cytosol] (Gallus gallus)

COPA [cytosol] (Plasmodium falciparum)

COPA [cytosol] (Schizosaccharomyces pombe)

COPA [cytosol] (Sus scrofa)

copa-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_004362.2, NP_001091868.1

OpenTargets

ENSG00000122218

HPA

ENSG00000122218-COPA

GeneCards

P53621

Ensembl

ENSP00000357048, ENSP00000241704, ENST00000368069, ENSG00000122218, ENST00000241704

PRO

P53621

Pharos - Targets

P53621

Orphanet

23594

HMDB Protein

HMDBP08329

PDB

6TZT, 6U3V, 6PBG

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	16
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.527	2
UniProt:Q8WUJ3 CEMIP	1	CEMIP [extracellular region] (R-HSA-5693352)	0.499	2

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