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Membrane Trafficking
Stable Identifier
R-HSA-199991
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
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The secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is made up of distinct organelles, including the endoplasmic reticulum (ER), Golgi complex, plasma membrane, and tubulovesicular transport intermediates. These organelles mediate intracellular membrane transport between themselves and the cell surface. Membrane traffic within this system flows along highly organized directional routes. Secretory cargo is synthesized and assembled in the ER and then transported to the Golgi complex for further processing and maturation. Upon arrival at the trans Golgi network (TGN), the cargo is sorted and packaged into post-Golgi carriers that move through the cytoplasm to fuse with the cell surface. This directional membrane flow is balanced by retrieval pathways that bring membrane and selected proteins back to the compartment of origin.
Literature References
PubMed ID
Title
Journal
Year
11031247
Secretory protein trafficking and organelle dynamics in living cells
Lippincott-Schwartz, J
,
Roberts, TH
,
Hirschberg, K
Annu Rev Cell Dev Biol
2000
Participants
Events
ER to Golgi Anterograde Transport
(Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic
(Homo sapiens)
trans-Golgi Network Vesicle Budding
(Homo sapiens)
Gap junction trafficking and regulation
(Homo sapiens)
Clathrin-mediated endocytosis
(Homo sapiens)
Endosomal Sorting Complex Required For Transport (ESCRT)
(Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane
(Homo sapiens)
Rab regulation of trafficking
(Homo sapiens)
Participates
as an event of
Vesicle-mediated transport (Homo sapiens)
Event Information
Go Biological Process
membrane organization (0061024)
Orthologous Events
Membrane Trafficking (Bos taurus)
Membrane Trafficking (Caenorhabditis elegans)
Membrane Trafficking (Canis familiaris)
Membrane Trafficking (Danio rerio)
Membrane Trafficking (Dictyostelium discoideum)
Membrane Trafficking (Drosophila melanogaster)
Membrane Trafficking (Gallus gallus)
Membrane Trafficking (Mus musculus)
Membrane Trafficking (Plasmodium falciparum)
Membrane Trafficking (Rattus norvegicus)
Membrane Trafficking (Saccharomyces cerevisiae)
Membrane Trafficking (Schizosaccharomyces pombe)
Membrane Trafficking (Sus scrofa)
Membrane Trafficking (Xenopus tropicalis)
Created
Gillespie, ME (2007-07-14)
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