trans-Golgi Network Vesicle Budding

Stable Identifier
R-HSA-199992
Type
Pathway
Species
Homo sapiens
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After passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membrane. There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat.

Literature References
PubMed ID Title Journal Year
11252894 Three ways to make a vesicle

Kirchhausen, Tomas

Nat Rev Mol Cell Biol 2000
Participants
Participant Of
Event Information
Orthologous Events
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Created