Reactome | PCOLCE [extracellular region]

PCOLCE [extracellular region]

Stable Identifier

R-HSA-2002444

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

PCPE1, Procollagen C-endopeptidase enhancer 1, PCOC1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15113 PCOLCE

Gene Names

PCOLCE, PCPE1

Chain

signal peptide:1-25, chain:26-449

Reference Genes

BioGPS Gene:5118 PCOLCE

COSMIC (genes):PCOLCE PCOLCE

CTD Gene:5118 PCOLCE

dbSNP Gene:5118 PCOLCE

ENSEMBL:ENSG00000106333 PCOLCE

HGNC:8738 PCOLCE

KEGG Gene (Homo sapiens):5118 PCOLCE

Monarch:5118 PCOLCE

NCBI Gene:5118 PCOLCE

OMIM:600270 PCOLCE

UCSC:Q15113 PCOLCE

Reference Transcript

RefSeq:NM_002593.3 PCOLCE

Other Identifiers

0006940315

11715652_a_at

17049408

17623

1UAP

202465_at

3015683

3015684

3015686

3015687

3015693

3015696

3015699

3015700

3015701

3015702

3015703

31609_s_at

42927

5118

6FZV

6FZW

8134869

A_23_P251499

AAA61949

AAC78800

AAD16041

AAH00574

AAH33205

AB008549

AF053356

AF083655

AK313748

BAA23281

BAG36488

BC000574

BC033205

CAB017623

CCDS5700

CH471091

EAW76515

ENSG00000106333

ENSP00000223061

ENST00000223061

ENST00000223061.5

EntrezGene:5118

EntrezGene:PCOLCE

g7262388_3p_at

GE62586

GO:0003674

GO:0005198

GO:0005201

GO:0005515

GO:0005518

GO:0005575

GO:0005576

GO:0005615

GO:0006508

GO:0007275

GO:0008150

GO:0008201

GO:0010952

GO:0016504

GO:0030234

GO:0031012

GO:0043167

GO:0043226

GO:0048856

GO:0062023

GO:0070062

GO:1990830

HGNC:8738

HPA042927

IPR000859

IPR001134

IPR008993

IPR018933

IPR028870

IPR035814

IPR035914

L33799

L33799_at

MIM:600270

NM_002593

NP_002584

PCOLCE

PCOLCE-201

PF00431

PF01759

PH_hs_0011876

SM00042

SM00643

TC07000627.hg

UPI0000131428

Participant Of

hasMember

PCOLCEs [extracellular region]

hasComponent

TLL2:PCPE1 [extracellular region]

Inferred To

Homologues of PCOLCE [extracellular region] (Danio rerio)

Homologues of PCOLCE [extracellular region] (Drosophila melanogaster)

PCOLCE [extracellular region] (Bos taurus)

PCOLCE [extracellular region] (Caenorhabditis elegans)

PCOLCE [extracellular region] (Canis familiaris)

PCOLCE [extracellular region] (Danio rerio)

PCOLCE [extracellular region] (Drosophila melanogaster)

PCOLCE [extracellular region] (Gallus gallus)

PCOLCE [extracellular region] (Mus musculus)

PCOLCE [extracellular region] (Rattus norvegicus)

PCOLCE [extracellular region] (Sus scrofa)

PCOLCE [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_002584.2

OpenTargets

ENSG00000106333

GeneCards

Q15113

PRO

Q15113

PDB

6FZW, 1UAP, 6FZV

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43407 Sdc2	30	phospho-p-SDC2 [endoplasmic reticulum lumen] (R-MMU-8956945) phospho-p-Y179,Y191-SDC2 [plasma membrane] (R-MMU-4093306) SDC2 [endoplasmic reticulum lumen] (R-MMU-8956741) SDC2 [plasma membrane] (R-MMU-2090052) HS(2)-Sdc2 [Golgi lumen] (R-MMU-2161438) HS(1)-Sdc2 [Golgi lumen] (R-MMU-2161462) Heparan-SDC2 [Golgi lumen] (R-MMU-2076608) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-MMU-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-MMU-2063997) Gal-Xyl-SDC2 [Golgi lumen] (R-MMU-2064132) XylS-SDC2 [Golgi lumen] (R-MMU-2064109) SDC2 [Golgi lumen] (R-MMU-2054101) HS(6)-SDC2 [lysosomal lumen] (R-MMU-2090064) SDC2 [lysosomal lumen] (R-MMU-2090083) HS(6)-SDC2 [plasma membrane] (R-MMU-2076661) HS(3)-SDC2 [Golgi lumen] (R-MMU-2076443) HS(5)-SDC2 [Golgi lumen] (R-MMU-2076320) HS(1)-SDC2 [Golgi lumen] (R-MMU-2076607) HS(2)-SDC2 [Golgi lumen] (R-MMU-2076603) HS(4)-SDC2 [Golgi lumen] (R-MMU-2076356) HS(6)-SDC2 [Golgi lumen] (R-MMU-2076588) HS(4)-SDC2 [plasma membrane] (R-MMU-2076683) HS(1)-SDC2 [plasma membrane] (R-MMU-2076643) HS(2)-SDC2 [plasma membrane] (R-MMU-2076644) HS(5)-SDC2 [plasma membrane] (R-MMU-2076665) HS(3)-SDC2 [plasma membrane] (R-MMU-2076631) Heparan(4)-SDC2 [Golgi lumen] (R-MMU-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-MMU-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-MMU-2076397) Heparan(1)-SDC2 [Golgi lumen] (R-MMU-2076536)	0.576	4
UniProt:P07996 THBS1	5	glc-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5172997) THBS1 [endoplasmic reticulum lumen] (R-HSA-5173263) O-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5173278) THBS1 [platelet alpha granule lumen] (R-HSA-114701) THBS1 [extracellular region] (R-HSA-66518)	0.558	3
UniProt:P18828 Sdc1	29	HS(1)-Sdc1 [extracellular region] (R-MMU-2731145) HS(2)-Sdc1 [extracellular region] (R-MMU-2731129) SDC1 [plasma membrane] (R-MMU-174758) HS(2)-Sdc1 [Golgi lumen] (R-MMU-2161443) HS(1)-Sdc1 [Golgi lumen] (R-MMU-2161455) Heparan-SDC1 [Golgi lumen] (R-MMU-2076561) Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-MMU-2064247) GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-MMU-2064082) Gal-Xyl-SDC1 [Golgi lumen] (R-MMU-2064148) XylS-SDC1 [Golgi lumen] (R-MMU-2064146) SDC1 [Golgi lumen] (R-MMU-2054105) HS(6)-SDC1 [lysosomal lumen] (R-MMU-2090082) SDC1 [lysosomal lumen] (R-MMU-2090025) HS(6)-SDC1 [plasma membrane] (R-MMU-2076652) HS(3)-SDC1 [Golgi lumen] (R-MMU-2076444) HS(5)-SDC1 [Golgi lumen] (R-MMU-2076290) HS(1)-SDC1 [Golgi lumen] (R-MMU-2076321) HS(2)-SDC1 [Golgi lumen] (R-MMU-2076309) HS(4)-SDC1 [Golgi lumen] (R-MMU-2076593) HS(6)-SDC1 [Golgi lumen] (R-MMU-2076520) HS(4)-SDC1 [plasma membrane] (R-MMU-2076693) HS(1)-SDC1 [plasma membrane] (R-MMU-2076672) HS(2)-SDC1 [plasma membrane] (R-MMU-2076666) HS(5)-SDC1 [plasma membrane] (R-MMU-2076626) HS(3)-SDC1 [plasma membrane] (R-MMU-2076691) Heparan(4)-SDC1 [Golgi lumen] (R-MMU-2076339) Heparan(3)-SDC1 [Golgi lumen] (R-MMU-2076314) Heparan(2)-SDC1 [Golgi lumen] (R-MMU-2076558) Heparan(1)-SDC1 [Golgi lumen] (R-MMU-2076349)	0.499	4